Ganciclovir penetrates into the cerebrospinal fluid of an infant with congenital cytomegalovirus infection

Currently, there is no evidence whether ganciclovir, or its oral prodrug valganciclovir, penetrates into the cerebrospinal fluid of human infants treated for congenital cytomegalovirus infection. Here, we report a case study providing evidence that ganciclovir, administered as valganciclovir, reache...

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Detalles Bibliográficos
Autores principales: Natale, Fabio, Bizzarri, Bianca, Cardi, Veronica, Gaeta, Aurelia, Villani, Paola, Liuzzi, Giuseppina, De Curtis, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389576/
https://www.ncbi.nlm.nih.gov/pubmed/25888518
http://dx.doi.org/10.1186/s13052-015-0132-8
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author Natale, Fabio
Bizzarri, Bianca
Cardi, Veronica
Gaeta, Aurelia
Villani, Paola
Liuzzi, Giuseppina
De Curtis, Mario
author_facet Natale, Fabio
Bizzarri, Bianca
Cardi, Veronica
Gaeta, Aurelia
Villani, Paola
Liuzzi, Giuseppina
De Curtis, Mario
author_sort Natale, Fabio
collection PubMed
description Currently, there is no evidence whether ganciclovir, or its oral prodrug valganciclovir, penetrates into the cerebrospinal fluid of human infants treated for congenital cytomegalovirus infection. Here, we report a case study providing evidence that ganciclovir, administered as valganciclovir, reaches the infant’s cerebrospinal fluid when used at the currently recommended dose for congenital cytomegalovirus infection.
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spelling pubmed-43895762015-04-09 Ganciclovir penetrates into the cerebrospinal fluid of an infant with congenital cytomegalovirus infection Natale, Fabio Bizzarri, Bianca Cardi, Veronica Gaeta, Aurelia Villani, Paola Liuzzi, Giuseppina De Curtis, Mario Ital J Pediatr Case Report Currently, there is no evidence whether ganciclovir, or its oral prodrug valganciclovir, penetrates into the cerebrospinal fluid of human infants treated for congenital cytomegalovirus infection. Here, we report a case study providing evidence that ganciclovir, administered as valganciclovir, reaches the infant’s cerebrospinal fluid when used at the currently recommended dose for congenital cytomegalovirus infection. BioMed Central 2015-03-31 /pmc/articles/PMC4389576/ /pubmed/25888518 http://dx.doi.org/10.1186/s13052-015-0132-8 Text en © Natale et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Natale, Fabio
Bizzarri, Bianca
Cardi, Veronica
Gaeta, Aurelia
Villani, Paola
Liuzzi, Giuseppina
De Curtis, Mario
Ganciclovir penetrates into the cerebrospinal fluid of an infant with congenital cytomegalovirus infection
title Ganciclovir penetrates into the cerebrospinal fluid of an infant with congenital cytomegalovirus infection
title_full Ganciclovir penetrates into the cerebrospinal fluid of an infant with congenital cytomegalovirus infection
title_fullStr Ganciclovir penetrates into the cerebrospinal fluid of an infant with congenital cytomegalovirus infection
title_full_unstemmed Ganciclovir penetrates into the cerebrospinal fluid of an infant with congenital cytomegalovirus infection
title_short Ganciclovir penetrates into the cerebrospinal fluid of an infant with congenital cytomegalovirus infection
title_sort ganciclovir penetrates into the cerebrospinal fluid of an infant with congenital cytomegalovirus infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389576/
https://www.ncbi.nlm.nih.gov/pubmed/25888518
http://dx.doi.org/10.1186/s13052-015-0132-8
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