Homozygous deletions of UGT2B17 modifies effects of smoking on TP53-mutations and relapse of head and neck carcinoma

BACKGROUND: Smoking induces oncogenic TP53-mutations in head and neck squamous cell carcinomas (HNSCCs). Disruptive mutations of TP53-gene and expression of p16 protein [p16 (+)] in tumor tissue associate with worse and better prognosis, respectively. UDP-glucuronosyltransferase 2 family, polypeptid...

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Detalles Bibliográficos
Autores principales: Mafune, Aki, Hama, Takanori, Suda, Toshihito, Suzuki, Yutaka, Ikegami, Masahiro, Sakanashi, Chikako, Imai, Satoko, Nakashima, Akio, Yokoo, Takashi, Wada, Kota, Kojima, Hiromi, Urashima, Mitsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389803/
https://www.ncbi.nlm.nih.gov/pubmed/25886176
http://dx.doi.org/10.1186/s12885-015-1220-2

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