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mTORC1 Maintains the Tumorigenicity of SSEA-4(+) High-Grade Osteosarcoma

Inactivation of p53 and/or Rb pathways restrains osteoblasts from cell-cycle exit and terminal differentiation, which underpins osteosarcoma formation coupled with dedifferentiation. Recently, the level of p-S6K was shown to independently predict the prognosis for osteosarcomas, while the reason beh...

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Detalles Bibliográficos
Autores principales:	Zhang, Wu, Ding, Meng-Lei, Zhang, Jia-Nian, Qiu, Jian-Ru, Shen, Yu-Hui, Ding, Xiao-Yi, Deng, Lian-Fu, Zhang, Wei-Bin, Zhu, Jiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389812/ https://www.ncbi.nlm.nih.gov/pubmed/25853231 http://dx.doi.org/10.1038/srep09604

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