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Use of second-generation antipsychotics in the acute inpatient management of schizophrenia in the Middle East

BACKGROUND: Management of acute psychotic episodes in schizophrenic patients remains a significant challenge for clinicians. Despite treatment guidelines recommending that second-generation antipsychotics (SGAs) should be used as monotherapy, first-generation antipsychotics, polypharmacy, and lower...

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Autores principales: Alkhadhari, Sulaiman, Al Zain, Nasser, Darwish, Tarek, Khan, Suhail, Okasha, Tarek, Ramy, Hisham, Tadros, Talaat Matar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389914/
https://www.ncbi.nlm.nih.gov/pubmed/25897227
http://dx.doi.org/10.2147/NDT.S78788
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author Alkhadhari, Sulaiman
Al Zain, Nasser
Darwish, Tarek
Khan, Suhail
Okasha, Tarek
Ramy, Hisham
Tadros, Talaat Matar
author_facet Alkhadhari, Sulaiman
Al Zain, Nasser
Darwish, Tarek
Khan, Suhail
Okasha, Tarek
Ramy, Hisham
Tadros, Talaat Matar
author_sort Alkhadhari, Sulaiman
collection PubMed
description BACKGROUND: Management of acute psychotic episodes in schizophrenic patients remains a significant challenge for clinicians. Despite treatment guidelines recommending that second-generation antipsychotics (SGAs) should be used as monotherapy, first-generation antipsychotics, polypharmacy, and lower than recommended doses are frequently administered in clinical practice. Minimal data exist regarding the use of SGAs in the Middle East. The objective of this study was to examine the discrepancies between current clinical practice and guideline recommendations in the region. METHODS: RECONNECT-S Beta was a multicenter, noninterventional study conducted in Egypt, Kuwait, Saudi Arabia, and the United Arab Emirates to observe the management of schizophrenic patients who were hospitalized due to an acute psychotic episode. Patients underwent one visit on the day of discharge. Demographic and medical history, together with data on antipsychotic treatment and concomitant medication during the hospitalization period and medication recommendations at discharge were recorded. RESULTS: Of the 1,057 patients, 180 (17.0%) and 692 (65.5%) received SGAs as monotherapy and in combination therapy, respectively. Overall, the most frequently administered medications were given orally, and included risperidone (40.3%), olanzapine (32.5%), and quetiapine (24.6%); the doses administered varied between countries and deviated from the recommended guidelines. Upon discharge, 93.9% of patients were prescribed SGAs as maintenance therapy, and 84.8% were prescribed the same medication(s) as during hospitalization. CONCLUSION: Current clinical practice in the Middle East differs from guideline recommendations. Patients frequently received antipsychotics in combination therapy, by various methods of administration, and at doses above and below the recommended guidelines for the management of their acute psychotic episodes.
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spelling pubmed-43899142015-04-20 Use of second-generation antipsychotics in the acute inpatient management of schizophrenia in the Middle East Alkhadhari, Sulaiman Al Zain, Nasser Darwish, Tarek Khan, Suhail Okasha, Tarek Ramy, Hisham Tadros, Talaat Matar Neuropsychiatr Dis Treat Original Research BACKGROUND: Management of acute psychotic episodes in schizophrenic patients remains a significant challenge for clinicians. Despite treatment guidelines recommending that second-generation antipsychotics (SGAs) should be used as monotherapy, first-generation antipsychotics, polypharmacy, and lower than recommended doses are frequently administered in clinical practice. Minimal data exist regarding the use of SGAs in the Middle East. The objective of this study was to examine the discrepancies between current clinical practice and guideline recommendations in the region. METHODS: RECONNECT-S Beta was a multicenter, noninterventional study conducted in Egypt, Kuwait, Saudi Arabia, and the United Arab Emirates to observe the management of schizophrenic patients who were hospitalized due to an acute psychotic episode. Patients underwent one visit on the day of discharge. Demographic and medical history, together with data on antipsychotic treatment and concomitant medication during the hospitalization period and medication recommendations at discharge were recorded. RESULTS: Of the 1,057 patients, 180 (17.0%) and 692 (65.5%) received SGAs as monotherapy and in combination therapy, respectively. Overall, the most frequently administered medications were given orally, and included risperidone (40.3%), olanzapine (32.5%), and quetiapine (24.6%); the doses administered varied between countries and deviated from the recommended guidelines. Upon discharge, 93.9% of patients were prescribed SGAs as maintenance therapy, and 84.8% were prescribed the same medication(s) as during hospitalization. CONCLUSION: Current clinical practice in the Middle East differs from guideline recommendations. Patients frequently received antipsychotics in combination therapy, by various methods of administration, and at doses above and below the recommended guidelines for the management of their acute psychotic episodes. Dove Medical Press 2015-04-01 /pmc/articles/PMC4389914/ /pubmed/25897227 http://dx.doi.org/10.2147/NDT.S78788 Text en © 2015 Alkhadhari et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Alkhadhari, Sulaiman
Al Zain, Nasser
Darwish, Tarek
Khan, Suhail
Okasha, Tarek
Ramy, Hisham
Tadros, Talaat Matar
Use of second-generation antipsychotics in the acute inpatient management of schizophrenia in the Middle East
title Use of second-generation antipsychotics in the acute inpatient management of schizophrenia in the Middle East
title_full Use of second-generation antipsychotics in the acute inpatient management of schizophrenia in the Middle East
title_fullStr Use of second-generation antipsychotics in the acute inpatient management of schizophrenia in the Middle East
title_full_unstemmed Use of second-generation antipsychotics in the acute inpatient management of schizophrenia in the Middle East
title_short Use of second-generation antipsychotics in the acute inpatient management of schizophrenia in the Middle East
title_sort use of second-generation antipsychotics in the acute inpatient management of schizophrenia in the middle east
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389914/
https://www.ncbi.nlm.nih.gov/pubmed/25897227
http://dx.doi.org/10.2147/NDT.S78788
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