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Environmental Trigger(s) of Type 1 Diabetes: Why So Difficult to Identify?
Type 1 diabetes (T1D) is one of the most common chronic diseases with childhood onset, and the disease has increased two- to fivefold over the past half century by as yet unknown means. T1D occurs when the body's immune system turns against itself so that, in a very specific and targeted way, i...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390105/ https://www.ncbi.nlm.nih.gov/pubmed/25883954 http://dx.doi.org/10.1155/2015/321656 |
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author | Rønningen, Kjersti S. |
author_facet | Rønningen, Kjersti S. |
author_sort | Rønningen, Kjersti S. |
collection | PubMed |
description | Type 1 diabetes (T1D) is one of the most common chronic diseases with childhood onset, and the disease has increased two- to fivefold over the past half century by as yet unknown means. T1D occurs when the body's immune system turns against itself so that, in a very specific and targeted way, it destroys the pancreatic β-cells. T1D results from poorly defined interactions between susceptibility genes and environmental determinants. In contrast to the rapid progress in finding T1D genes, identification and confirmation of environmental determinants remain a formidable challenge. This review article will focus on factors which have to be evaluated and decision to take before starting a new prospective cohort study. Considering all the large ongoing prospective studies, new and more conclusive data than that obtained so far should instead come from international collaboration on the ongoing cohort studies. |
format | Online Article Text |
id | pubmed-4390105 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43901052015-04-16 Environmental Trigger(s) of Type 1 Diabetes: Why So Difficult to Identify? Rønningen, Kjersti S. Biomed Res Int Review Article Type 1 diabetes (T1D) is one of the most common chronic diseases with childhood onset, and the disease has increased two- to fivefold over the past half century by as yet unknown means. T1D occurs when the body's immune system turns against itself so that, in a very specific and targeted way, it destroys the pancreatic β-cells. T1D results from poorly defined interactions between susceptibility genes and environmental determinants. In contrast to the rapid progress in finding T1D genes, identification and confirmation of environmental determinants remain a formidable challenge. This review article will focus on factors which have to be evaluated and decision to take before starting a new prospective cohort study. Considering all the large ongoing prospective studies, new and more conclusive data than that obtained so far should instead come from international collaboration on the ongoing cohort studies. Hindawi Publishing Corporation 2015 2015-03-25 /pmc/articles/PMC4390105/ /pubmed/25883954 http://dx.doi.org/10.1155/2015/321656 Text en Copyright © 2015 Kjersti S. Rønningen. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Rønningen, Kjersti S. Environmental Trigger(s) of Type 1 Diabetes: Why So Difficult to Identify? |
title | Environmental Trigger(s) of Type 1 Diabetes: Why So Difficult to Identify? |
title_full | Environmental Trigger(s) of Type 1 Diabetes: Why So Difficult to Identify? |
title_fullStr | Environmental Trigger(s) of Type 1 Diabetes: Why So Difficult to Identify? |
title_full_unstemmed | Environmental Trigger(s) of Type 1 Diabetes: Why So Difficult to Identify? |
title_short | Environmental Trigger(s) of Type 1 Diabetes: Why So Difficult to Identify? |
title_sort | environmental trigger(s) of type 1 diabetes: why so difficult to identify? |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390105/ https://www.ncbi.nlm.nih.gov/pubmed/25883954 http://dx.doi.org/10.1155/2015/321656 |
work_keys_str_mv | AT rønningenkjerstis environmentaltriggersoftype1diabeteswhysodifficulttoidentify |