CK1δ restrains lipin-1 induction, lipid droplet formation and cell proliferation under hypoxia by reducing HIF-1α/ARNT complex formation

Proliferation of cells under hypoxia is facilitated by metabolic adaptation, mediated by the transcriptional activator Hypoxia Inducible Factor-1 (HIF-1). HIF-1α, the inducible subunit of HIF-1 is regulated by oxygen as well as by oxygen-independent mechanisms involving phosphorylation. We have prev...

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Detalles Bibliográficos
Autores principales: Kourti, Maria, Ikonomou, Georgia, Giakoumakis, Nikolaos-Nikiforos, Rapsomaniki, Maria Anna, Landegren, Ulf, Siniossoglou, Symeon, Lygerou, Zoi, Simos, George, Mylonis, Ilias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390155/
https://www.ncbi.nlm.nih.gov/pubmed/25744540
http://dx.doi.org/10.1016/j.cellsig.2015.02.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390155/
https://www.ncbi.nlm.nih.gov/pubmed/25744540
http://dx.doi.org/10.1016/j.cellsig.2015.02.017

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