Phosphorylation of Mutationally Introduced Tyrosine in the Activation Loop of HER2 Confers Gain-of-Function Activity

Amplification, overexpression, and somatic mutation of the HER2 gene have been reported to play a critical role in tumorigenesis of various cancers. The HER2 H878Y mutation was recently reported in 11% of hepatocellular carcinoma (HCC) patients. However, its functional impact on the HER2 protein and...

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Detalles Bibliográficos
Autores principales: Hu, Zexi, Wan, Xiaobo, Hao, Rui, Zhang, Heng, Li, Li, Li, Lin, Xie, Qiang, Wang, Peng, Gao, Yibo, Chen, She, Wei, Min, Luan, Zhidong, Zhang, Aiqun, Huang, Niu, Chen, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390223/
https://www.ncbi.nlm.nih.gov/pubmed/25853726
http://dx.doi.org/10.1371/journal.pone.0123623

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