Total Proteome Analysis Identifies Migration Defects as a Major Pathogenetic Factor in Immunoglobulin Heavy Chain Variable Region (IGHV)-unmutated Chronic Lymphocytic Leukemia

The mutational status of the immunoglobulin heavy chain variable region defines two clinically distinct forms of chronic lymphocytic leukemia (CLL) known as mutated (M-CLL) and unmutated (UM-CLL). To elucidate the molecular mechanisms underlying the adverse clinical outcome associated with UM-CLL, t...

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Detalles Bibliográficos
Autores principales: Eagle, Gina L., Zhuang, Jianguo, Jenkins, Rosalind E., Till, Kathleen J., Jithesh, Puthen V., Lin, Ke, Johnson, Gillian G., Oates, Melanie, Park, Kevin, Kitteringham, Neil R., Pettitt, Andrew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390271/
https://www.ncbi.nlm.nih.gov/pubmed/25645933
http://dx.doi.org/10.1074/mcp.M114.044479

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