Reduced Adolescent-Age Spatial Learning Ability Associated with Elevated Juvenile-Age Superoxide Levels in Complex I Mouse Mutants

Large-scale, heteroplasmic and generally pathogenic mtDNA defects (as induced by defective mitochondrial DNA polymerase, clonal mutations or DNA deletions) are known to negatively impact on life span and can result in apoptosis and tissue loss in, e.g., skeletal muscle or reduce learning abilities....

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Detalles Bibliográficos
Autores principales: Mayer, Johannes, Reichart, Gesine, Tokay, Tursonjan, Lange, Falko, Baltrusch, Simone, Junghanss, Christian, Wolkenhauer, Olaf, Jaster, Robert, Kunz, Manfred, Tiedge, Markus, Ibrahim, Saleh, Fuellen, Georg, Köhling, Rüdiger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390344/
https://www.ncbi.nlm.nih.gov/pubmed/25853418
http://dx.doi.org/10.1371/journal.pone.0123863

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