A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis

Detection of cyclic-di-adenosine monophosphate (c-di-AMP), a bacterial second messenger, by the host cytoplasmic surveillance pathway (CSP) is known to elicit Type I interferon responses critical for antimicrobial defense(1–3). However, the mechanisms and role of c-di-AMP signaling in Mycobacterium...

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Detalles Bibliográficos
Autores principales: Dey, Bappaditya, Dey, Ruchi Jain, Cheung, Laurene S., Pokkali, Supriya, Guo, Haidan, Lee, Jong-Hee, Bishai, William R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390473/
https://www.ncbi.nlm.nih.gov/pubmed/25730264
http://dx.doi.org/10.1038/nm.3813

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390473/
https://www.ncbi.nlm.nih.gov/pubmed/25730264
http://dx.doi.org/10.1038/nm.3813

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