Cargando…

A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis

Detection of cyclic-di-adenosine monophosphate (c-di-AMP), a bacterial second messenger, by the host cytoplasmic surveillance pathway (CSP) is known to elicit Type I interferon responses critical for antimicrobial defense(1–3). However, the mechanisms and role of c-di-AMP signaling in Mycobacterium...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dey, Bappaditya, Dey, Ruchi Jain, Cheung, Laurene S., Pokkali, Supriya, Guo, Haidan, Lee, Jong-Hee, Bishai, William R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390473/ https://www.ncbi.nlm.nih.gov/pubmed/25730264 http://dx.doi.org/10.1038/nm.3813

Ejemplares similares

Augmentation of the Riboflavin-Biosynthetic Pathway Enhances Mucosa-Associated Invariant T (MAIT) Cell Activation and Diminishes Mycobacterium tuberculosis Virulence
por: Dey, Ruchi Jain, et al.
Publicado: (2022)

Cyclic dinucleotides mediate bacterial immunity by dinucleotide cyclase in Vibrio
por: Lu, Zengzeng, et al.
Publicado: (2022)

The World of Cyclic Dinucleotides in Bacterial Behavior
por: Aline Dias da, Purificação, et al.
Publicado: (2020)

Polymersome-mediated cytosolic delivery of cyclic dinucleotide STING agonist enhances tumor immunotherapy
por: Zheng, Huan, et al.
Publicado: (2022)

Activation of Gingival Fibroblasts by Bacterial Cyclic Dinucleotides and Lipopolysaccharide
por: Elmanfi, Samira, et al.
Publicado: (2020)

Adjunctive immunotherapy with α-crystallin based DNA vaccination reduces Tuberculosis chemotherapy period in chronically infected mice
por: Chauhan, Priyanka, et al.
Publicado: (2013)

Regulation of gingival epithelial cytokine response by bacterial cyclic dinucleotides
por: Elmanfi, Samira, et al.
Publicado: (2018)

Development of the first oligonucleotide microarray for global gene expression profiling in guinea pigs: defining the transcription signature of infectious diseases
por: Jain, Ruchi, et al.
Publicado: (2012)

Enzymatic synthesis of cyclic dinucleotide analogs by a promiscuous cyclic-AMP-GMP synthetase and analysis of cyclic dinucleotide responsive riboswitches
por: Launer-Felty, Katherine D, et al.
Publicado: (2018)

The Age of Cyclic Dinucleotide Vaccine Adjuvants
por: Gogoi, Himanshu, et al.
Publicado: (2020)

Single Nucleotide Polymorphisms of Human STING Can Affect Innate Immune Response to Cyclic Dinucleotides
por: Yi, Guanghui, et al.
Publicado: (2013)

Supramolecular polymer formation by cyclic dinucleotides and intercalators affects dinucleotide enzymatic processing
por: Nakayama, Shizuka, et al.
Publicado: (2016)

Vaccination with Recombinant Mycobacterium tuberculosis PknD Attenuates Bacterial Dissemination to the Brain in Guinea Pigs
por: Skerry, Ciaran, et al.
Publicado: (2013)

Perspectives for Developing New Tuberculosis Vaccines Derived from the Pathogenesis of Tuberculosis: I. Basic Principles, II. Preclinical Testing, and III. Clinical Testing
por: Dannenberg, Arthur M., et al.
Publicado: (2013)

Highly Efficient Preparation of Cyclic Dinucleotides via Engineering of Dinucleotide Cyclases in Escherichia coli
por: Lv, Yun, et al.
Publicado: (2019)

Cyclic Dinucleotides in Oral Bacteria and in Oral Biofilms
por: Gürsoy, Ulvi K., et al.
Publicado: (2017)

STING cyclic dinucleotide sensing originated in bacteria
por: Morehouse, Benjamin R., et al.
Publicado: (2020)

A Booster Vaccine Expressing a Latency-Associated Antigen Augments BCG Induced Immunity and Confers Enhanced Protection against Tuberculosis
por: Dey, Bappaditya, et al.
Publicado: (2011)

Mass spectrometric characterization of cyclic dinucleotides (CDNs) in vivo
por: Annibal, Andrea, et al.
Publicado: (2021)

STING inhibitors target the cyclic dinucleotide binding pocket
por: Hong, Ze, et al.
Publicado: (2021)

Bacterial Cyclic Dinucleotides and the cGAS–cGAMP–STING Pathway: A Role in Periodontitis?
por: Elmanfi, Samira, et al.
Publicado: (2021)

Investigating cyclic nucleotide and cyclic dinucleotide binding to HCN channels by surface plasmon resonance
por: Hayoz, Sebastien, et al.
Publicado: (2017)

Quantitation of cyclic dinucleotides by reversed-phase LC-MS/MS
por: Spangler, Christian, et al.
Publicado: (2009)

SLC19A1 transports immunoreactive cyclic dinucleotides
por: Luteijn, Rutger D., et al.
Publicado: (2019)

The Promise and Challenges of Cyclic Dinucleotides as Molecular Adjuvants for Vaccine Development
por: Yan, Hongbin, et al.
Publicado: (2021)

Chemical Synthesis of the Fluorescent, Cyclic Dinucleotides c(th)GAMP
por: Veth, Simon, et al.
Publicado: (2022)

Biocatalytic Synthesis of Antiviral Nucleosides, Cyclic Dinucleotides, and Oligonucleotide Therapies
por: Van Giesen, Kyle J. D., et al.
Publicado: (2022)

Global proteomics of fibroblast cells treated with bacterial cyclic dinucleotides, c-di-GMP and c-di-AMP
por: Onyedibe, Kenneth I., et al.
Publicado: (2021)

Cyclic dinucleotides (CDNs) reversed T cells tolerance in anti-tumor immunotherapy
por: Fu, Juan, et al.
Publicado: (2015)

Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides
por: Cao, Xueli, et al.
Publicado: (2023)

Enhanced and Enduring Protection against Tuberculosis by Recombinant BCG-Ag85C and Its Association with Modulation of Cytokine Profile in Lung
por: Jain, Ruchi, et al.
Publicado: (2008)

Bacterial Ligands Generated in a Phagosome Are Targets of the Cytosolic Innate Immune System
por: Herskovits, Anat A, et al.
Publicado: (2007)

Divergent proinflammatory immune responses associated with the differential susceptibility of cattle breeds to tuberculosis
por: Kumar, Rishi, et al.
Publicado: (2023)

Cyclic dinucleotides (CDNs) anti-tumors response by activating DC and NK cell crosstalk
por: Fu, Juan, et al.
Publicado: (2014)

Endosomolytic Polymersomes Increase the Activity of Cyclic Dinucleotide STING Agonists to Enhance Cancer Immunotherapy
por: Shae, Daniel, et al.
Publicado: (2019)

Extracellular cyclic dinucleotides induce polarized responses in barrier epithelial cells by adenosine signaling
por: Chang, Denis, et al.
Publicado: (2020)

Amplifying STING Activation by Cyclic Dinucleotide-Manganese Particles for Local and Systemic Cancer Metalloimmunotherapy
por: Sun, Xiaoqi, et al.
Publicado: (2021)

A computational pipeline for quantification of pulmonary infections in small animal models using serial PET-CT imaging
por: Bagci, Ulas, et al.
Publicado: (2013)

Latency Antigen α-Crystallin Based Vaccination Imparts a Robust Protection against TB by Modulating the Dynamics of Pulmonary Cytokines
por: Dey, Bappaditya, et al.
Publicado: (2011)

Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide
por: Omura, Hiroki, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_sk86u3pnmp11psicuvds53r84q