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I’m Positive, But I’m Negative: Competing Voices in Informed Consent and Implications for HIV Vaccine Trials

HIV vaccine trials (HVTs) are ethically complex, and sound informed consent processes should facilitate optimal decision-making for participants. This study aimed to explore representations of critical HVT-related concepts to enhance the consent process. Four focus group discussions were conducted w...

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Detalles Bibliográficos
Autores principales: Rautenbach, Clinton, Lindegger, Graham, Slack, Catherine, Wallace, Melissa, Newman, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390555/
https://www.ncbi.nlm.nih.gov/pubmed/25819758
http://dx.doi.org/10.1177/1556264615575509
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author Rautenbach, Clinton
Lindegger, Graham
Slack, Catherine
Wallace, Melissa
Newman, Peter
author_facet Rautenbach, Clinton
Lindegger, Graham
Slack, Catherine
Wallace, Melissa
Newman, Peter
author_sort Rautenbach, Clinton
collection PubMed
description HIV vaccine trials (HVTs) are ethically complex, and sound informed consent processes should facilitate optimal decision-making for participants. This study aimed to explore representations of critical HVT-related concepts to enhance the consent process. Four focus group discussions were conducted with participants from key constituencies at a South African HVT site. Thematic analysis was employed to identify representations of key HVT-related concepts. The findings suggest that (potential) participants may negotiate multiple, competing versions of HVT-related concepts in a somewhat unrecognized process, which may have significant implications for the consent process. Stakeholders involved in consent and engagement activities at sites should be assisted to elicit, engage, and resolve competing representations of HVT-related concepts. More empirical research is needed to explore how such stakeholders address competing representations in their interactions with potential participants.
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spelling pubmed-43905552015-05-15 I’m Positive, But I’m Negative: Competing Voices in Informed Consent and Implications for HIV Vaccine Trials Rautenbach, Clinton Lindegger, Graham Slack, Catherine Wallace, Melissa Newman, Peter J Empir Res Hum Res Ethics Informed Consent HIV vaccine trials (HVTs) are ethically complex, and sound informed consent processes should facilitate optimal decision-making for participants. This study aimed to explore representations of critical HVT-related concepts to enhance the consent process. Four focus group discussions were conducted with participants from key constituencies at a South African HVT site. Thematic analysis was employed to identify representations of key HVT-related concepts. The findings suggest that (potential) participants may negotiate multiple, competing versions of HVT-related concepts in a somewhat unrecognized process, which may have significant implications for the consent process. Stakeholders involved in consent and engagement activities at sites should be assisted to elicit, engage, and resolve competing representations of HVT-related concepts. More empirical research is needed to explore how such stakeholders address competing representations in their interactions with potential participants. SAGE Publications 2015-04 /pmc/articles/PMC4390555/ /pubmed/25819758 http://dx.doi.org/10.1177/1556264615575509 Text en © The Author(s) 2015 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (http://www.uk.sagepub.com/aboutus/openaccess.htm).
spellingShingle Informed Consent
Rautenbach, Clinton
Lindegger, Graham
Slack, Catherine
Wallace, Melissa
Newman, Peter
I’m Positive, But I’m Negative: Competing Voices in Informed Consent and Implications for HIV Vaccine Trials
title I’m Positive, But I’m Negative: Competing Voices in Informed Consent and Implications for HIV Vaccine Trials
title_full I’m Positive, But I’m Negative: Competing Voices in Informed Consent and Implications for HIV Vaccine Trials
title_fullStr I’m Positive, But I’m Negative: Competing Voices in Informed Consent and Implications for HIV Vaccine Trials
title_full_unstemmed I’m Positive, But I’m Negative: Competing Voices in Informed Consent and Implications for HIV Vaccine Trials
title_short I’m Positive, But I’m Negative: Competing Voices in Informed Consent and Implications for HIV Vaccine Trials
title_sort i’m positive, but i’m negative: competing voices in informed consent and implications for hiv vaccine trials
topic Informed Consent
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390555/
https://www.ncbi.nlm.nih.gov/pubmed/25819758
http://dx.doi.org/10.1177/1556264615575509
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