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Immunological Profiling of Obesity
It is widely accepted that chronic inflammation contributes to the pathogenesis of obesity. Researchers have recently discovered that increased inflammatory cytokines and the infiltration and activation of macrophage cells in the adipose tissue are related to chronic obesity. This immunologic dysreg...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Institute of Lifestyle Medicine, Yonsei University Wonju College of Medicine
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390759/ https://www.ncbi.nlm.nih.gov/pubmed/26064849 http://dx.doi.org/10.15280/jlm.2014.4.1.1 |
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author | Ignacio, Rosa Mistica C. Kim, Cheol-Su Kim, Soo-Ki |
author_facet | Ignacio, Rosa Mistica C. Kim, Cheol-Su Kim, Soo-Ki |
author_sort | Ignacio, Rosa Mistica C. |
collection | PubMed |
description | It is widely accepted that chronic inflammation contributes to the pathogenesis of obesity. Researchers have recently discovered that increased inflammatory cytokines and the infiltration and activation of macrophage cells in the adipose tissue are related to chronic obesity. This immunologic dysregulation has led to the development of the classical pro-inflammatory paradigm. However, since chronic inflammation associated with obesity is more than just the overproduction of pro-inflammatory cytokines, precise dissection requires beyond the classical pro-inflammatory cytokines. The purpose of this review is to summarize the immunological profiling of obesity for theragnostic convenience, focusing on the cytokine and adipokine network in obesity and the significance of the balance of Th1/Th2 immunity. |
format | Online Article Text |
id | pubmed-4390759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Institute of Lifestyle Medicine, Yonsei University Wonju College of Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-43907592015-06-10 Immunological Profiling of Obesity Ignacio, Rosa Mistica C. Kim, Cheol-Su Kim, Soo-Ki J Lifestyle Med Review Article It is widely accepted that chronic inflammation contributes to the pathogenesis of obesity. Researchers have recently discovered that increased inflammatory cytokines and the infiltration and activation of macrophage cells in the adipose tissue are related to chronic obesity. This immunologic dysregulation has led to the development of the classical pro-inflammatory paradigm. However, since chronic inflammation associated with obesity is more than just the overproduction of pro-inflammatory cytokines, precise dissection requires beyond the classical pro-inflammatory cytokines. The purpose of this review is to summarize the immunological profiling of obesity for theragnostic convenience, focusing on the cytokine and adipokine network in obesity and the significance of the balance of Th1/Th2 immunity. Institute of Lifestyle Medicine, Yonsei University Wonju College of Medicine 2014-03 2014-03-31 /pmc/articles/PMC4390759/ /pubmed/26064849 http://dx.doi.org/10.15280/jlm.2014.4.1.1 Text en © 2014 Journal of Lifestyle Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Ignacio, Rosa Mistica C. Kim, Cheol-Su Kim, Soo-Ki Immunological Profiling of Obesity |
title | Immunological Profiling of Obesity |
title_full | Immunological Profiling of Obesity |
title_fullStr | Immunological Profiling of Obesity |
title_full_unstemmed | Immunological Profiling of Obesity |
title_short | Immunological Profiling of Obesity |
title_sort | immunological profiling of obesity |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390759/ https://www.ncbi.nlm.nih.gov/pubmed/26064849 http://dx.doi.org/10.15280/jlm.2014.4.1.1 |
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