From Formamide to RNA, the Path Is Tenuous but Continuous

Reactions of formamide (NH(2)COH) in the presence of catalysts of both terrestrial and meteoritic origin yield, in plausible and variegated conditions, a large panel of precursors of (pre)genetic and (pre)metabolic interest. Formamide chemistry potentially satisfies all of the steps from the very in...

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Detalles Bibliográficos
Autores principales: Pino, Samanta, Sponer, Judit E., Costanzo, Giovanna, Saladino, Raffaele, Di Mauro, Ernesto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4390857/
https://www.ncbi.nlm.nih.gov/pubmed/25647486
http://dx.doi.org/10.3390/life5010372
Descripción
Sumario:Reactions of formamide (NH(2)COH) in the presence of catalysts of both terrestrial and meteoritic origin yield, in plausible and variegated conditions, a large panel of precursors of (pre)genetic and (pre)metabolic interest. Formamide chemistry potentially satisfies all of the steps from the very initial precursors to RNA. Water chemistry enters the scene in RNA non-enzymatic synthesis and recombination.

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