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APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice

BACKGROUND: Alzheimer’s disease (AD) causes progressive loss of memory and cognition, exacerbated by APOE4, the greatest genetic risk factor for AD. One proposed mechanism for apolipoprotein E (apoE) effects on cognition is via NMDAR-dependent signaling. APOE genotype-specific effects on this pathwa...

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Detalles Bibliográficos
Autores principales:	Liu, De-shan, Pan, Xiao-dong, Zhang, Jing, Shen, Hui, Collins, Nicole C, Cole, Arron M, Koster, Kevin P, Ben Aissa, Manel, Dai, Xiao-man, Zhou, Meng, Tai, Leon M, Zhu, Yuan-gui, LaDu, Mary Jo, Chen, Xiao-chun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391134/ https://www.ncbi.nlm.nih.gov/pubmed/25871877 http://dx.doi.org/10.1186/s13024-015-0002-2

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