MUSiCC: a marker genes based framework for metagenomic normalization and accurate profiling of gene abundances in the microbiome

Functional metagenomic analyses commonly involve a normalization step, where measured levels of genes or pathways are converted into relative abundances. Here, we demonstrate that this normalization scheme introduces marked biases both across and within human microbiome samples, and identify sample-...

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Detalles Bibliográficos
Autores principales: Manor, Ohad, Borenstein, Elhanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391136/
https://www.ncbi.nlm.nih.gov/pubmed/25885687
http://dx.doi.org/10.1186/s13059-015-0610-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391136/
https://www.ncbi.nlm.nih.gov/pubmed/25885687
http://dx.doi.org/10.1186/s13059-015-0610-8

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