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PVT1: A Rising Star among Oncogenic Long Noncoding RNAs

It is becoming increasingly clear that short and long noncoding RNAs critically participate in the regulation of cell growth, differentiation, and (mis)function. However, while the functional characterization of short non-coding RNAs has been reaching maturity, there is still a paucity of well chara...

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Detalles Bibliográficos
Autores principales: Colombo, Teresa, Farina, Lorenzo, Macino, Giuseppe, Paci, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391155/
https://www.ncbi.nlm.nih.gov/pubmed/25883951
http://dx.doi.org/10.1155/2015/304208
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author Colombo, Teresa
Farina, Lorenzo
Macino, Giuseppe
Paci, Paola
author_facet Colombo, Teresa
Farina, Lorenzo
Macino, Giuseppe
Paci, Paola
author_sort Colombo, Teresa
collection PubMed
description It is becoming increasingly clear that short and long noncoding RNAs critically participate in the regulation of cell growth, differentiation, and (mis)function. However, while the functional characterization of short non-coding RNAs has been reaching maturity, there is still a paucity of well characterized long noncoding RNAs, even though large studies in recent years are rapidly increasing the number of annotated ones. The long noncoding RNA PVT1 is encoded by a gene that has been long known since it resides in the well-known cancer risk region 8q24. However, a couple of accidental concurrent conditions have slowed down the study of this gene, that is, a preconception on the primacy of the protein-coding over noncoding RNAs and the prevalent interest in its neighbor MYC oncogene. Recent studies have brought PVT1 under the spotlight suggesting interesting models of functioning, such as competing endogenous RNA activity and regulation of protein stability of important oncogenes, primarily of the MYC oncogene. Despite some advancements in modelling the PVT1 role in cancer, there are many questions that remain unanswered concerning the precise molecular mechanisms underlying its functioning.
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spelling pubmed-43911552015-04-16 PVT1: A Rising Star among Oncogenic Long Noncoding RNAs Colombo, Teresa Farina, Lorenzo Macino, Giuseppe Paci, Paola Biomed Res Int Review Article It is becoming increasingly clear that short and long noncoding RNAs critically participate in the regulation of cell growth, differentiation, and (mis)function. However, while the functional characterization of short non-coding RNAs has been reaching maturity, there is still a paucity of well characterized long noncoding RNAs, even though large studies in recent years are rapidly increasing the number of annotated ones. The long noncoding RNA PVT1 is encoded by a gene that has been long known since it resides in the well-known cancer risk region 8q24. However, a couple of accidental concurrent conditions have slowed down the study of this gene, that is, a preconception on the primacy of the protein-coding over noncoding RNAs and the prevalent interest in its neighbor MYC oncogene. Recent studies have brought PVT1 under the spotlight suggesting interesting models of functioning, such as competing endogenous RNA activity and regulation of protein stability of important oncogenes, primarily of the MYC oncogene. Despite some advancements in modelling the PVT1 role in cancer, there are many questions that remain unanswered concerning the precise molecular mechanisms underlying its functioning. Hindawi Publishing Corporation 2015 2015-03-26 /pmc/articles/PMC4391155/ /pubmed/25883951 http://dx.doi.org/10.1155/2015/304208 Text en Copyright © 2015 Teresa Colombo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Colombo, Teresa
Farina, Lorenzo
Macino, Giuseppe
Paci, Paola
PVT1: A Rising Star among Oncogenic Long Noncoding RNAs
title PVT1: A Rising Star among Oncogenic Long Noncoding RNAs
title_full PVT1: A Rising Star among Oncogenic Long Noncoding RNAs
title_fullStr PVT1: A Rising Star among Oncogenic Long Noncoding RNAs
title_full_unstemmed PVT1: A Rising Star among Oncogenic Long Noncoding RNAs
title_short PVT1: A Rising Star among Oncogenic Long Noncoding RNAs
title_sort pvt1: a rising star among oncogenic long noncoding rnas
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391155/
https://www.ncbi.nlm.nih.gov/pubmed/25883951
http://dx.doi.org/10.1155/2015/304208
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