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PVT1: A Rising Star among Oncogenic Long Noncoding RNAs
It is becoming increasingly clear that short and long noncoding RNAs critically participate in the regulation of cell growth, differentiation, and (mis)function. However, while the functional characterization of short non-coding RNAs has been reaching maturity, there is still a paucity of well chara...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391155/ https://www.ncbi.nlm.nih.gov/pubmed/25883951 http://dx.doi.org/10.1155/2015/304208 |
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author | Colombo, Teresa Farina, Lorenzo Macino, Giuseppe Paci, Paola |
author_facet | Colombo, Teresa Farina, Lorenzo Macino, Giuseppe Paci, Paola |
author_sort | Colombo, Teresa |
collection | PubMed |
description | It is becoming increasingly clear that short and long noncoding RNAs critically participate in the regulation of cell growth, differentiation, and (mis)function. However, while the functional characterization of short non-coding RNAs has been reaching maturity, there is still a paucity of well characterized long noncoding RNAs, even though large studies in recent years are rapidly increasing the number of annotated ones. The long noncoding RNA PVT1 is encoded by a gene that has been long known since it resides in the well-known cancer risk region 8q24. However, a couple of accidental concurrent conditions have slowed down the study of this gene, that is, a preconception on the primacy of the protein-coding over noncoding RNAs and the prevalent interest in its neighbor MYC oncogene. Recent studies have brought PVT1 under the spotlight suggesting interesting models of functioning, such as competing endogenous RNA activity and regulation of protein stability of important oncogenes, primarily of the MYC oncogene. Despite some advancements in modelling the PVT1 role in cancer, there are many questions that remain unanswered concerning the precise molecular mechanisms underlying its functioning. |
format | Online Article Text |
id | pubmed-4391155 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-43911552015-04-16 PVT1: A Rising Star among Oncogenic Long Noncoding RNAs Colombo, Teresa Farina, Lorenzo Macino, Giuseppe Paci, Paola Biomed Res Int Review Article It is becoming increasingly clear that short and long noncoding RNAs critically participate in the regulation of cell growth, differentiation, and (mis)function. However, while the functional characterization of short non-coding RNAs has been reaching maturity, there is still a paucity of well characterized long noncoding RNAs, even though large studies in recent years are rapidly increasing the number of annotated ones. The long noncoding RNA PVT1 is encoded by a gene that has been long known since it resides in the well-known cancer risk region 8q24. However, a couple of accidental concurrent conditions have slowed down the study of this gene, that is, a preconception on the primacy of the protein-coding over noncoding RNAs and the prevalent interest in its neighbor MYC oncogene. Recent studies have brought PVT1 under the spotlight suggesting interesting models of functioning, such as competing endogenous RNA activity and regulation of protein stability of important oncogenes, primarily of the MYC oncogene. Despite some advancements in modelling the PVT1 role in cancer, there are many questions that remain unanswered concerning the precise molecular mechanisms underlying its functioning. Hindawi Publishing Corporation 2015 2015-03-26 /pmc/articles/PMC4391155/ /pubmed/25883951 http://dx.doi.org/10.1155/2015/304208 Text en Copyright © 2015 Teresa Colombo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Colombo, Teresa Farina, Lorenzo Macino, Giuseppe Paci, Paola PVT1: A Rising Star among Oncogenic Long Noncoding RNAs |
title | PVT1: A Rising Star among Oncogenic Long Noncoding RNAs |
title_full | PVT1: A Rising Star among Oncogenic Long Noncoding RNAs |
title_fullStr | PVT1: A Rising Star among Oncogenic Long Noncoding RNAs |
title_full_unstemmed | PVT1: A Rising Star among Oncogenic Long Noncoding RNAs |
title_short | PVT1: A Rising Star among Oncogenic Long Noncoding RNAs |
title_sort | pvt1: a rising star among oncogenic long noncoding rnas |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391155/ https://www.ncbi.nlm.nih.gov/pubmed/25883951 http://dx.doi.org/10.1155/2015/304208 |
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