Simultaneous Onset of Alzheimer’s Disease in a Husband and Wife in Their Mid-Fifties: What Do We Really Know About Environmental Factors?

INTRODUCTION: Environmental factors can play a role in the pathogenesis of Alzheimer’s disease. We present a case of the simultaneous onset of Alzheimer’s disease in two middle aged adults. CASE PRESENTATION: A married couple ages 54 year and 51-year-old female cohabiting together were diagnosed wit...

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Detalles Bibliográficos
Autores principales: Pelcovits, Ari, Marriotti, Rachel, Heath, Jonathan, Perry, George, Castellani, Rudy J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Open 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391217/
https://www.ncbi.nlm.nih.gov/pubmed/25932054
http://dx.doi.org/10.2174/1874205X01509010001
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author Pelcovits, Ari
Marriotti, Rachel
Heath, Jonathan
Perry, George
Castellani, Rudy J
author_facet Pelcovits, Ari
Marriotti, Rachel
Heath, Jonathan
Perry, George
Castellani, Rudy J
author_sort Pelcovits, Ari
collection PubMed
description INTRODUCTION: Environmental factors can play a role in the pathogenesis of Alzheimer’s disease. We present a case of the simultaneous onset of Alzheimer’s disease in two middle aged adults. CASE PRESENTATION: A married couple ages 54 year and 51-year-old female cohabiting together were diagnosed with Alzheimer’s disease within the same year. The patient’s both developed cognitive decline shortly after a major renovation of their property and followed a similar disease course. The diagnosis was supported by clinical presentation and tissue pathology on autopsy. CONCLUSION: Environmental factors may play a role in the pathogenesis of Alzheimer’s disease. Further understanding of the disease cascade is required.
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spelling pubmed-43912172015-04-30 Simultaneous Onset of Alzheimer’s Disease in a Husband and Wife in Their Mid-Fifties: What Do We Really Know About Environmental Factors? Pelcovits, Ari Marriotti, Rachel Heath, Jonathan Perry, George Castellani, Rudy J Open Neurol J Article INTRODUCTION: Environmental factors can play a role in the pathogenesis of Alzheimer’s disease. We present a case of the simultaneous onset of Alzheimer’s disease in two middle aged adults. CASE PRESENTATION: A married couple ages 54 year and 51-year-old female cohabiting together were diagnosed with Alzheimer’s disease within the same year. The patient’s both developed cognitive decline shortly after a major renovation of their property and followed a similar disease course. The diagnosis was supported by clinical presentation and tissue pathology on autopsy. CONCLUSION: Environmental factors may play a role in the pathogenesis of Alzheimer’s disease. Further understanding of the disease cascade is required. Bentham Open 2015-03-31 /pmc/articles/PMC4391217/ /pubmed/25932054 http://dx.doi.org/10.2174/1874205X01509010001 Text en © Pelcovits et al.; Licensee Bentham Open. http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Pelcovits, Ari
Marriotti, Rachel
Heath, Jonathan
Perry, George
Castellani, Rudy J
Simultaneous Onset of Alzheimer’s Disease in a Husband and Wife in Their Mid-Fifties: What Do We Really Know About Environmental Factors?
title Simultaneous Onset of Alzheimer’s Disease in a Husband and Wife in Their Mid-Fifties: What Do We Really Know About Environmental Factors?
title_full Simultaneous Onset of Alzheimer’s Disease in a Husband and Wife in Their Mid-Fifties: What Do We Really Know About Environmental Factors?
title_fullStr Simultaneous Onset of Alzheimer’s Disease in a Husband and Wife in Their Mid-Fifties: What Do We Really Know About Environmental Factors?
title_full_unstemmed Simultaneous Onset of Alzheimer’s Disease in a Husband and Wife in Their Mid-Fifties: What Do We Really Know About Environmental Factors?
title_short Simultaneous Onset of Alzheimer’s Disease in a Husband and Wife in Their Mid-Fifties: What Do We Really Know About Environmental Factors?
title_sort simultaneous onset of alzheimer’s disease in a husband and wife in their mid-fifties: what do we really know about environmental factors?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391217/
https://www.ncbi.nlm.nih.gov/pubmed/25932054
http://dx.doi.org/10.2174/1874205X01509010001
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