Is arginase a potential drug target in tobacco-induced pulmonary endothelial dysfunction?

BACKGROUND: Tobacco-induced pulmonary vascular disease is partly driven by endothelial dysfunction. The bioavailability of the potent vasodilator nitric oxide (NO) depends on competition between NO synthase-3 (NOS3) and arginases for their common substrate (L-arginine). We tested the hypothesis wher...

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Detalles Bibliográficos
Autores principales: Henno, Priscilla, Maurey, Christelle, Le Pimpec-Barthes, Françoise, Devillier, Philippe, Delclaux, Christophe, Israël-Biet, Dominique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391310/
https://www.ncbi.nlm.nih.gov/pubmed/25889611
http://dx.doi.org/10.1186/s12931-015-0196-4

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