Clinical significance of HPV-DNA testing for precancerous cervical lesionS

Cervical screening by using cytology was proven efficient in reducing the mortality secondary to cervical cancer, but this method has limitations. High risk HPV infection is essential for cervical cancer development so HPV testing is a new tool used for screening patients for cervical neoplasia. HPV...

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Detalles Bibliográficos
Autores principales: Moarcăs, M, Georgescu, IC, Brătilă, E, Badea, M, Cîrstoiu, ECM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Carol Davila University Press 2014
Materias:
General Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391422/
https://www.ncbi.nlm.nih.gov/pubmed/25870692
Descripción
Sumario:Cervical screening by using cytology was proven efficient in reducing the mortality secondary to cervical cancer, but this method has limitations. High risk HPV infection is essential for cervical cancer development so HPV testing is a new tool used for screening patients for cervical neoplasia. HPV testing was proven most useful for women over 30 years old, in cases in which cytology identified ASC-US and after treatment for CIN. This article outlines the clinical significance of HPV-DNA testing for precancerous cervical lesions and the evidence that stands behind these recommendations. Abbreviations: HPV = Human Papilloma Virus, ASC-US = Atypical Squamous Cells of Undetermined Significance, CIN = Cervical Intraepithelial Neoplasia, LSIL = Low Grade Squamous Intraepithelial Lesion, DNA = Deoxyribonucleic Acid

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