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Evaluation of biological safety in vitro and immunogenicity in vivo of recombinant Escherichia coli Shiga toxoids as candidate vaccines in cattle

Cattle are the most important reservoir for enterohemorrhagic Escherichia coli (EHEC), a subset of shigatoxigenic E. coli (STEC) capable of causing life-threatening infectious diseases in humans. In cattle, Shiga toxins (Stx) suppress the immune system thereby promoting long-term STEC shedding. Firs...

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Detalles Bibliográficos
Autores principales:	Kerner, Katharina, Bridger, Philip S, Köpf, Gabriele, Fröhlich, Julia, Barth, Stefanie, Willems, Hermann, Bauerfeind, Rolf, Baljer, Georg, Menge, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391668/ https://www.ncbi.nlm.nih.gov/pubmed/25889651 http://dx.doi.org/10.1186/s13567-015-0175-2

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