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Regulatory T cell-deficient scurfy mice develop systemic autoimmune features resembling lupus-like disease

INTRODUCTION: Scurfy mice are deficient in regulatory T cells (Tregs), develop a severe, generalized autoimmune disorder that can affect almost every organ and die at an early age. Some of these manifestations resemble those found in systemic lupus erythematosus (SLE). In addition, active SLE is ass...

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Detalles Bibliográficos
Autores principales:	Hadaschik, Eva N, Wei, Xiaoying, Leiss, Harald, Heckmann, Britta, Niederreiter, Birgit, Steiner, Günter, Ulrich, Walter, Enk, Alexander H, Smolen, Josef S, Stummvoll, Georg H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391674/ https://www.ncbi.nlm.nih.gov/pubmed/25890083 http://dx.doi.org/10.1186/s13075-015-0538-0

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