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Insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains
The role of insulin in the brain is still not completely understood. In the periphery, insulin can decrease inflammation induced by lipopolysaccharide (LPS); however, whether insulin can reduce inflammation within the brain is unknown. Experiments administrating intranasal insulin to young and aged...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391678/ https://www.ncbi.nlm.nih.gov/pubmed/25889938 http://dx.doi.org/10.1186/s12974-015-0282-z |
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author | Adzovic, Linda Lynn, Ashley E D’Angelo, Heather M Crockett, Alexis M Kaercher, Roxanne M Royer, Sarah E Hopp, Sarah C Wenk, Gary L |
author_facet | Adzovic, Linda Lynn, Ashley E D’Angelo, Heather M Crockett, Alexis M Kaercher, Roxanne M Royer, Sarah E Hopp, Sarah C Wenk, Gary L |
author_sort | Adzovic, Linda |
collection | PubMed |
description | The role of insulin in the brain is still not completely understood. In the periphery, insulin can decrease inflammation induced by lipopolysaccharide (LPS); however, whether insulin can reduce inflammation within the brain is unknown. Experiments administrating intranasal insulin to young and aged adults have shown that insulin improves memory. In our animal model of chronic neuroinflammation, we administered insulin and/or LPS directly into the brain via the fourth ventricle for 4 weeks in young rats; we then analyzed their spatial memory and neuroinflammatory response. Additionally, we administered insulin or artificial cerebral spinal fluid (aCSF), in the same manner, to aged rats and then analyzed their spatial memory and neuroinflammatory response. Response to chronic neuroinflammation in young rats was analyzed in the presence or absence of insulin supplementation. Here, we show for the first time that insulin infused (i.c.v.) to young rats significantly attenuated the effects of LPS by decreasing the expression of neuroinflammatory markers in the hippocampus and by improving performance in the Morris water pool task. In young rats, insulin infusion alone significantly improved their performance as compared to all other groups. Unexpectedly, in aged rats, the responsiveness to insulin was completely absent, that is, spatial memory was still impaired suggesting that an age-dependent insulin resistance may contribute to the cognitive impairment observed in neurodegenerative diseases. Our data suggest a novel therapeutic effect of insulin on neuroinflammation in the young but not the aged brain. |
format | Online Article Text |
id | pubmed-4391678 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-43916782015-04-10 Insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains Adzovic, Linda Lynn, Ashley E D’Angelo, Heather M Crockett, Alexis M Kaercher, Roxanne M Royer, Sarah E Hopp, Sarah C Wenk, Gary L J Neuroinflammation Research The role of insulin in the brain is still not completely understood. In the periphery, insulin can decrease inflammation induced by lipopolysaccharide (LPS); however, whether insulin can reduce inflammation within the brain is unknown. Experiments administrating intranasal insulin to young and aged adults have shown that insulin improves memory. In our animal model of chronic neuroinflammation, we administered insulin and/or LPS directly into the brain via the fourth ventricle for 4 weeks in young rats; we then analyzed their spatial memory and neuroinflammatory response. Additionally, we administered insulin or artificial cerebral spinal fluid (aCSF), in the same manner, to aged rats and then analyzed their spatial memory and neuroinflammatory response. Response to chronic neuroinflammation in young rats was analyzed in the presence or absence of insulin supplementation. Here, we show for the first time that insulin infused (i.c.v.) to young rats significantly attenuated the effects of LPS by decreasing the expression of neuroinflammatory markers in the hippocampus and by improving performance in the Morris water pool task. In young rats, insulin infusion alone significantly improved their performance as compared to all other groups. Unexpectedly, in aged rats, the responsiveness to insulin was completely absent, that is, spatial memory was still impaired suggesting that an age-dependent insulin resistance may contribute to the cognitive impairment observed in neurodegenerative diseases. Our data suggest a novel therapeutic effect of insulin on neuroinflammation in the young but not the aged brain. BioMed Central 2015-04-02 /pmc/articles/PMC4391678/ /pubmed/25889938 http://dx.doi.org/10.1186/s12974-015-0282-z Text en © Adzovic et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Adzovic, Linda Lynn, Ashley E D’Angelo, Heather M Crockett, Alexis M Kaercher, Roxanne M Royer, Sarah E Hopp, Sarah C Wenk, Gary L Insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains |
title | Insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains |
title_full | Insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains |
title_fullStr | Insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains |
title_full_unstemmed | Insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains |
title_short | Insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains |
title_sort | insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391678/ https://www.ncbi.nlm.nih.gov/pubmed/25889938 http://dx.doi.org/10.1186/s12974-015-0282-z |
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