Development and analytical validation of a 25-gene next generation sequencing panel that includes the BRCA1 and BRCA2 genes to assess hereditary cancer risk

BACKGROUND: Germline DNA mutations that increase the susceptibility of a patient to certain cancers have been identified in various genes, and patients can be screened for mutations in these genes to assess their level of risk for developing cancer. Traditional methods using Sanger sequencing focus...

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Detalles Bibliográficos
Autores principales: Judkins, Thaddeus, Leclair, Benoît, Bowles, Karla, Gutin, Natalia, Trost, Jeff, McCulloch, James, Bhatnagar, Satish, Murray, Adam, Craft, Jonathan, Wardell, Bryan, Bastian, Mark, Mitchell, Jeffrey, Chen, Jian, Tran, Thanh, Williams, Deborah, Potter, Jennifer, Jammulapati, Srikanth, Perry, Michael, Morris, Brian, Roa, Benjamin, Timms, Kirsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Technical Advance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391687/
https://www.ncbi.nlm.nih.gov/pubmed/25886519
http://dx.doi.org/10.1186/s12885-015-1224-y

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