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Associations of betatrophin levels with irisin in Chinese women with normal glucose tolerance

BACKGROUND: Betatrophin may increase islet β cell proliferation in insulin resistance and irisin may improve glucose tolerance in mice. To examine the relationship between betatrophin and irisin, we investigated it in middle-aged Chinese subjects with normal glucose tolerance (NGT) and type 2 diabet...

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Autores principales: Xie, Xinmiao, Gao, Ting, Yang, Meili, Chen, Peihong, Jin, Hua, Yang, Lili, Yu, Xuemei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391688/
https://www.ncbi.nlm.nih.gov/pubmed/25859278
http://dx.doi.org/10.1186/s13098-015-0019-2
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author Xie, Xinmiao
Gao, Ting
Yang, Meili
Chen, Peihong
Jin, Hua
Yang, Lili
Yu, Xuemei
author_facet Xie, Xinmiao
Gao, Ting
Yang, Meili
Chen, Peihong
Jin, Hua
Yang, Lili
Yu, Xuemei
author_sort Xie, Xinmiao
collection PubMed
description BACKGROUND: Betatrophin may increase islet β cell proliferation in insulin resistance and irisin may improve glucose tolerance in mice. To examine the relationship between betatrophin and irisin, we investigated it in middle-aged Chinese subjects with normal glucose tolerance (NGT) and type 2 diabetes mellitus (T2DM). METHODS: A total of 460 permanent residents of Fengxian District, aged 40–60 years and without T2DM, were enrolled. Anthropometric parameters, oral glucose tolerance test (OGTT) results, glycosylated haemoglobin levels, blood lipid levels, insulin sensitivity (homeostasis model assessment of insulin resistance, HOMA-IR), β cell function (homeostasis model assessment-β, HOMA-β), estimated glomerular filtration rate (eGFR) and body fat composition were determined. Matched for age, gender and body mass index (BMI, 18–28 kg/m2), newly diagnosed T2DM (n = 50, male/female = 23/27) and NGT (n = 50, male/female = 21/29) subjects were selected based on the results of an OGTT. Serum betatrophin and irisin levels were determined by enzyme linked immune sorbent assay (ELISA). RESULTS: Males had higher levels of betatrophin compared with females in both the NGT and T2DM groups. Compared with NGT subjects, the level of betatrophin in the T2DM group was higher, and males in the T2DM group had higher betatrophin levels than males in the NGT group, but there was no significant difference in betatrophin levels in females between the T2DM and NGT groups. Spearman’s correlation analysis revealed that serum betatrophin levels in females with NGT were positively correlated with irisin and negatively correlated with FINS (fasting insulin) levels ( p < 0.05), but no correlation was found between betatrophin and irisin levels in males with NGT or in males or females with T2DM. In females with T2DM, circulating betatrophin levels were positively correlated with weight, BMI and hip circumference (p < 0.05) but negatively correlated with FPG (fasting plasma glucose) and HOMA-IR (p < 0.05). CONCLUSIONS: Gender differences in the relationship between betatrophin and irisin indicate that there might be cytokine-mediated crosstalk among the liver, adipose tissue and skeletal muscle.
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spelling pubmed-43916882015-04-10 Associations of betatrophin levels with irisin in Chinese women with normal glucose tolerance Xie, Xinmiao Gao, Ting Yang, Meili Chen, Peihong Jin, Hua Yang, Lili Yu, Xuemei Diabetol Metab Syndr Research BACKGROUND: Betatrophin may increase islet β cell proliferation in insulin resistance and irisin may improve glucose tolerance in mice. To examine the relationship between betatrophin and irisin, we investigated it in middle-aged Chinese subjects with normal glucose tolerance (NGT) and type 2 diabetes mellitus (T2DM). METHODS: A total of 460 permanent residents of Fengxian District, aged 40–60 years and without T2DM, were enrolled. Anthropometric parameters, oral glucose tolerance test (OGTT) results, glycosylated haemoglobin levels, blood lipid levels, insulin sensitivity (homeostasis model assessment of insulin resistance, HOMA-IR), β cell function (homeostasis model assessment-β, HOMA-β), estimated glomerular filtration rate (eGFR) and body fat composition were determined. Matched for age, gender and body mass index (BMI, 18–28 kg/m2), newly diagnosed T2DM (n = 50, male/female = 23/27) and NGT (n = 50, male/female = 21/29) subjects were selected based on the results of an OGTT. Serum betatrophin and irisin levels were determined by enzyme linked immune sorbent assay (ELISA). RESULTS: Males had higher levels of betatrophin compared with females in both the NGT and T2DM groups. Compared with NGT subjects, the level of betatrophin in the T2DM group was higher, and males in the T2DM group had higher betatrophin levels than males in the NGT group, but there was no significant difference in betatrophin levels in females between the T2DM and NGT groups. Spearman’s correlation analysis revealed that serum betatrophin levels in females with NGT were positively correlated with irisin and negatively correlated with FINS (fasting insulin) levels ( p < 0.05), but no correlation was found between betatrophin and irisin levels in males with NGT or in males or females with T2DM. In females with T2DM, circulating betatrophin levels were positively correlated with weight, BMI and hip circumference (p < 0.05) but negatively correlated with FPG (fasting plasma glucose) and HOMA-IR (p < 0.05). CONCLUSIONS: Gender differences in the relationship between betatrophin and irisin indicate that there might be cytokine-mediated crosstalk among the liver, adipose tissue and skeletal muscle. BioMed Central 2015-03-25 /pmc/articles/PMC4391688/ /pubmed/25859278 http://dx.doi.org/10.1186/s13098-015-0019-2 Text en © Xie et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Xie, Xinmiao
Gao, Ting
Yang, Meili
Chen, Peihong
Jin, Hua
Yang, Lili
Yu, Xuemei
Associations of betatrophin levels with irisin in Chinese women with normal glucose tolerance
title Associations of betatrophin levels with irisin in Chinese women with normal glucose tolerance
title_full Associations of betatrophin levels with irisin in Chinese women with normal glucose tolerance
title_fullStr Associations of betatrophin levels with irisin in Chinese women with normal glucose tolerance
title_full_unstemmed Associations of betatrophin levels with irisin in Chinese women with normal glucose tolerance
title_short Associations of betatrophin levels with irisin in Chinese women with normal glucose tolerance
title_sort associations of betatrophin levels with irisin in chinese women with normal glucose tolerance
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391688/
https://www.ncbi.nlm.nih.gov/pubmed/25859278
http://dx.doi.org/10.1186/s13098-015-0019-2
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