Structural Modeling of a Novel CAPN5 Mutation that Causes Uveitis and Neovascular Retinal Detachment

CAPN5 mutations have been linked to autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV), a blinding autoimmune eye disease. Here, we link a new CAPN5 mutation to ADNIV and model the three-dimensional structure of the resulting mutant protein. In our study, a kindred with inflammato...

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Detalles Bibliográficos
Autores principales: Bassuk, Alexander G., Yeh, Steven, Wu, Shu, Martin, Daniel F., Tsang, Stephen H., Gakhar, Lokesh, Mahajan, Vinit B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391918/
https://www.ncbi.nlm.nih.gov/pubmed/25856303
http://dx.doi.org/10.1371/journal.pone.0122352

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