CT features of pulmonary arterial hypertension and its major subtypes: a systematic CT evaluation of 292 patients from the ASPIRE Registry

We evaluated the prevalence and prognostic value of CT-pulmonary angiographic (CTPA) measures in 292 treatment naive patients with pulmonary arterial hypertension (PAH). Pulmonary artery calcification (13%) and thrombus (10%) were exclusively seen in PAH-congenital heart disease. Oesophageal dilatio...

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Autores principales: Rajaram, S, Swift, A J, Condliffe, R, Johns, C, Elliot, C A, Hill, C, Davies, C, Hurdman, J, Sabroe, I, Wild, J M, Kiely, D G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2015
Materias:
Chest Clinic
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392204/
https://www.ncbi.nlm.nih.gov/pubmed/25523307
http://dx.doi.org/10.1136/thoraxjnl-2014-206088
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author Rajaram, S
Swift, A J
Condliffe, R
Johns, C
Elliot, C A
Hill, C
Davies, C
Hurdman, J
Sabroe, I
Wild, J M
Kiely, D G
author_facet Rajaram, S
Swift, A J
Condliffe, R
Johns, C
Elliot, C A
Hill, C
Davies, C
Hurdman, J
Sabroe, I
Wild, J M
Kiely, D G
author_sort Rajaram, S
collection PubMed
description We evaluated the prevalence and prognostic value of CT-pulmonary angiographic (CTPA) measures in 292 treatment naive patients with pulmonary arterial hypertension (PAH). Pulmonary artery calcification (13%) and thrombus (10%) were exclusively seen in PAH-congenital heart disease. Oesophageal dilation (46%) was most frequent in PAH-systemic sclerosis. Ground glass opacification (GGO) (41%), pericardial effusion (38%), lymphadenopathy (19%) and pleural effusion (11%) were common. On multivariate analysis, inferior vena caval area, the presence of pleural effusion and septal lines predicted outcome. In PAH, CTPA provides diagnostic and prognostic information. In addition, the presence of GGO on a CT performed for unexplained breathlessness should alert the physician to the possibility of PAH.
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spelling pubmed-43922042015-04-13 CT features of pulmonary arterial hypertension and its major subtypes: a systematic CT evaluation of 292 patients from the ASPIRE Registry Rajaram, S Swift, A J Condliffe, R Johns, C Elliot, C A Hill, C Davies, C Hurdman, J Sabroe, I Wild, J M Kiely, D G Thorax Chest Clinic We evaluated the prevalence and prognostic value of CT-pulmonary angiographic (CTPA) measures in 292 treatment naive patients with pulmonary arterial hypertension (PAH). Pulmonary artery calcification (13%) and thrombus (10%) were exclusively seen in PAH-congenital heart disease. Oesophageal dilation (46%) was most frequent in PAH-systemic sclerosis. Ground glass opacification (GGO) (41%), pericardial effusion (38%), lymphadenopathy (19%) and pleural effusion (11%) were common. On multivariate analysis, inferior vena caval area, the presence of pleural effusion and septal lines predicted outcome. In PAH, CTPA provides diagnostic and prognostic information. In addition, the presence of GGO on a CT performed for unexplained breathlessness should alert the physician to the possibility of PAH. BMJ Publishing Group 2015-04 2014-12-18 /pmc/articles/PMC4392204/ /pubmed/25523307 http://dx.doi.org/10.1136/thoraxjnl-2014-206088 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Chest Clinic
Rajaram, S
Swift, A J
Condliffe, R
Johns, C
Elliot, C A
Hill, C
Davies, C
Hurdman, J
Sabroe, I
Wild, J M
Kiely, D G
CT features of pulmonary arterial hypertension and its major subtypes: a systematic CT evaluation of 292 patients from the ASPIRE Registry
title CT features of pulmonary arterial hypertension and its major subtypes: a systematic CT evaluation of 292 patients from the ASPIRE Registry
title_full CT features of pulmonary arterial hypertension and its major subtypes: a systematic CT evaluation of 292 patients from the ASPIRE Registry
title_fullStr CT features of pulmonary arterial hypertension and its major subtypes: a systematic CT evaluation of 292 patients from the ASPIRE Registry
title_full_unstemmed CT features of pulmonary arterial hypertension and its major subtypes: a systematic CT evaluation of 292 patients from the ASPIRE Registry
title_short CT features of pulmonary arterial hypertension and its major subtypes: a systematic CT evaluation of 292 patients from the ASPIRE Registry
title_sort ct features of pulmonary arterial hypertension and its major subtypes: a systematic ct evaluation of 292 patients from the aspire registry
topic Chest Clinic
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392204/
https://www.ncbi.nlm.nih.gov/pubmed/25523307
http://dx.doi.org/10.1136/thoraxjnl-2014-206088
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