The Major Autoantibody Epitope on Factor H in Atypical Hemolytic Uremic Syndrome Is Structurally Different from Its Homologous Site in Factor H-related Protein 1, Supporting a Novel Model for Induction of Autoimmunity in This Disease

Atypical hemolytic uremic syndrome (aHUS) is characterized by complement attack against host cells due to mutations in complement proteins or autoantibodies against complement factor H (CFH). It is unknown why nearly all patients with autoimmune aHUS lack CFHR1 (CFH-related protein-1). These patient...

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Detalles Bibliográficos
Autores principales: Bhattacharjee, Arnab, Reuter, Stefanie, Trojnár, Eszter, Kolodziejczyk, Robert, Seeberger, Harald, Hyvärinen, Satu, Uzonyi, Barbara, Szilágyi, Ágnes, Prohászka, Zoltán, Goldman, Adrian, Józsi, Mihály, Jokiranta, T. Sakari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392255/
https://www.ncbi.nlm.nih.gov/pubmed/25659429
http://dx.doi.org/10.1074/jbc.M114.630871

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