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Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study

OBJECTIVES: To describe trends in the epidemiology of gout and patterns of urate-lowering treatment (ULT) in the UK general population from 1997 to 2012. METHODS: We used the Clinical Practice Research Datalink to estimate the prevalence and incidence of gout for each calendar year from 1997 to 2012...

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Autores principales: Kuo, Chang-Fu, Grainge, Matthew J, Mallen, Christian, Zhang, Weiya, Doherty, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392307/
https://www.ncbi.nlm.nih.gov/pubmed/24431399
http://dx.doi.org/10.1136/annrheumdis-2013-204463
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author Kuo, Chang-Fu
Grainge, Matthew J
Mallen, Christian
Zhang, Weiya
Doherty, Michael
author_facet Kuo, Chang-Fu
Grainge, Matthew J
Mallen, Christian
Zhang, Weiya
Doherty, Michael
author_sort Kuo, Chang-Fu
collection PubMed
description OBJECTIVES: To describe trends in the epidemiology of gout and patterns of urate-lowering treatment (ULT) in the UK general population from 1997 to 2012. METHODS: We used the Clinical Practice Research Datalink to estimate the prevalence and incidence of gout for each calendar year from 1997 to 2012. We also investigated the pattern of gout management for both prevalent and incident gout patients. RESULTS: In 2012, the prevalence of gout was 2.49% (95% CI 2.48% to 2.51%) and the incidence was 1.77 (95% CI 1.73 to 1.81) per 1000 person-years. Prevalence and incidence both were significantly higher in 2012 than in 1997, with a 63.9% increase in prevalence and 29.6% increase in incidence over this period. Regions with highest prevalence and incidence were the North East and Wales. Among prevalent gout patients in 2012, only 48.48% (95% CI 48.08% to 48.89%) were being consulted specifically for gout or treated with ULT and of these 37.63% (95% CI 37.28% to 38.99%) received ULT. In addition, only 18.6% (95% CI 17.6% to 19.6%) of incident gout patients received ULT within 6 months and 27.3% (95% CI 26.1% to 28.5%) within 12 months of diagnosis. The management of prevalent and incident gout patients remained essentially the same during the study period, although the percentage of adherent patients improved from 28.28% (95% CI 27.33% to 29.26%) in 1997 to 39.66% (95% CI 39.11% to 40.22%) in 2012. CONCLUSIONS: In recent years, both the prevalence and incidence of gout have increased significantly in the UK. Suboptimal use of ULT has not changed between 1997 and 2012. Patient adherence has improved during the study period, but it remains poor.
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spelling pubmed-43923072015-04-13 Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study Kuo, Chang-Fu Grainge, Matthew J Mallen, Christian Zhang, Weiya Doherty, Michael Ann Rheum Dis Clinical and Epidemiological Research OBJECTIVES: To describe trends in the epidemiology of gout and patterns of urate-lowering treatment (ULT) in the UK general population from 1997 to 2012. METHODS: We used the Clinical Practice Research Datalink to estimate the prevalence and incidence of gout for each calendar year from 1997 to 2012. We also investigated the pattern of gout management for both prevalent and incident gout patients. RESULTS: In 2012, the prevalence of gout was 2.49% (95% CI 2.48% to 2.51%) and the incidence was 1.77 (95% CI 1.73 to 1.81) per 1000 person-years. Prevalence and incidence both were significantly higher in 2012 than in 1997, with a 63.9% increase in prevalence and 29.6% increase in incidence over this period. Regions with highest prevalence and incidence were the North East and Wales. Among prevalent gout patients in 2012, only 48.48% (95% CI 48.08% to 48.89%) were being consulted specifically for gout or treated with ULT and of these 37.63% (95% CI 37.28% to 38.99%) received ULT. In addition, only 18.6% (95% CI 17.6% to 19.6%) of incident gout patients received ULT within 6 months and 27.3% (95% CI 26.1% to 28.5%) within 12 months of diagnosis. The management of prevalent and incident gout patients remained essentially the same during the study period, although the percentage of adherent patients improved from 28.28% (95% CI 27.33% to 29.26%) in 1997 to 39.66% (95% CI 39.11% to 40.22%) in 2012. CONCLUSIONS: In recent years, both the prevalence and incidence of gout have increased significantly in the UK. Suboptimal use of ULT has not changed between 1997 and 2012. Patient adherence has improved during the study period, but it remains poor. BMJ Publishing Group 2015-04 2014-01-15 /pmc/articles/PMC4392307/ /pubmed/24431399 http://dx.doi.org/10.1136/annrheumdis-2013-204463 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Clinical and Epidemiological Research
Kuo, Chang-Fu
Grainge, Matthew J
Mallen, Christian
Zhang, Weiya
Doherty, Michael
Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study
title Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study
title_full Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study
title_fullStr Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study
title_full_unstemmed Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study
title_short Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study
title_sort rising burden of gout in the uk but continuing suboptimal management: a nationwide population study
topic Clinical and Epidemiological Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392307/
https://www.ncbi.nlm.nih.gov/pubmed/24431399
http://dx.doi.org/10.1136/annrheumdis-2013-204463
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