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Repeated resections for liver metastasis from primary adrenocortical carcinoma: A case report
INTRODUCTION: Adrenal cortical carcinoma (ACC) is a very rare type of tumor that generally has a poor prognosis. Little has been reported on repeated liver resections with recurrent metastasis still confined to the liver. In this report, we describe a case of functioning ACC in a 65-year-old woman w...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392357/ https://www.ncbi.nlm.nih.gov/pubmed/25765741 http://dx.doi.org/10.1016/j.ijscr.2015.02.041 |
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author | Nakano, Ryosuke Satoh, Daisuke Nakajima, Hirochika Yoshimura, Yuri Miyoshi, Hisanobu Yoshida, Kazuhiro Matsukawa, Hiroyoshi Shiozaki, Shigehiro Ichimura, Kouichi Okajima, Masazumi Ninomiya, Motoki |
author_facet | Nakano, Ryosuke Satoh, Daisuke Nakajima, Hirochika Yoshimura, Yuri Miyoshi, Hisanobu Yoshida, Kazuhiro Matsukawa, Hiroyoshi Shiozaki, Shigehiro Ichimura, Kouichi Okajima, Masazumi Ninomiya, Motoki |
author_sort | Nakano, Ryosuke |
collection | PubMed |
description | INTRODUCTION: Adrenal cortical carcinoma (ACC) is a very rare type of tumor that generally has a poor prognosis. Little has been reported on repeated liver resections with recurrent metastasis still confined to the liver. In this report, we describe a case of functioning ACC in a 65-year-old woman with 2 liver metastases of the ACC (at 1.5 and 4 years) after the right adrenalectomy. PRESENTATION OF CASE: A 65-year-old woman was referred to our hospital based on a suspicion of hyperaldosteronism. Abdominal computed tomography revealed a lesion at the right adrenal gland; therefore, we performed right adrenalectomy and subsequently diagnosed the lesion as ACC. However, follow-up computed tomography at 1.5 and 4 years after the right adrenalectomy revealed liver metastasis of ACC; liver resection was performed for both metastases. DISCUSSION: Complete surgical resection is the established approach for the treatment of ACC. The prognosis of ACC is usually dismal, and recurrence rates of up to 85% have been reported. However, the appropriate treatment for recurrent ACC is not well established, and the effectiveness of other modalities, such as chemotherapy and radiotherapy, is not proven. Therefore, surgical resection may currently be the most appropriate treatment modality, as the patient achieved a disease-free interval of 2.5 years after the first liver resection. CONCLUSION: In selected patients with recurrent or metastatic ACC, resection is likely to be associated with prolonged survival. However, a full cure is generally not achievable, and a multidisciplinary approach is likely needed to achieve long-term disease-free status and survival. |
format | Online Article Text |
id | pubmed-4392357 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-43923572015-04-13 Repeated resections for liver metastasis from primary adrenocortical carcinoma: A case report Nakano, Ryosuke Satoh, Daisuke Nakajima, Hirochika Yoshimura, Yuri Miyoshi, Hisanobu Yoshida, Kazuhiro Matsukawa, Hiroyoshi Shiozaki, Shigehiro Ichimura, Kouichi Okajima, Masazumi Ninomiya, Motoki Int J Surg Case Rep Case Report INTRODUCTION: Adrenal cortical carcinoma (ACC) is a very rare type of tumor that generally has a poor prognosis. Little has been reported on repeated liver resections with recurrent metastasis still confined to the liver. In this report, we describe a case of functioning ACC in a 65-year-old woman with 2 liver metastases of the ACC (at 1.5 and 4 years) after the right adrenalectomy. PRESENTATION OF CASE: A 65-year-old woman was referred to our hospital based on a suspicion of hyperaldosteronism. Abdominal computed tomography revealed a lesion at the right adrenal gland; therefore, we performed right adrenalectomy and subsequently diagnosed the lesion as ACC. However, follow-up computed tomography at 1.5 and 4 years after the right adrenalectomy revealed liver metastasis of ACC; liver resection was performed for both metastases. DISCUSSION: Complete surgical resection is the established approach for the treatment of ACC. The prognosis of ACC is usually dismal, and recurrence rates of up to 85% have been reported. However, the appropriate treatment for recurrent ACC is not well established, and the effectiveness of other modalities, such as chemotherapy and radiotherapy, is not proven. Therefore, surgical resection may currently be the most appropriate treatment modality, as the patient achieved a disease-free interval of 2.5 years after the first liver resection. CONCLUSION: In selected patients with recurrent or metastatic ACC, resection is likely to be associated with prolonged survival. However, a full cure is generally not achievable, and a multidisciplinary approach is likely needed to achieve long-term disease-free status and survival. Elsevier 2015-02-26 /pmc/articles/PMC4392357/ /pubmed/25765741 http://dx.doi.org/10.1016/j.ijscr.2015.02.041 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Nakano, Ryosuke Satoh, Daisuke Nakajima, Hirochika Yoshimura, Yuri Miyoshi, Hisanobu Yoshida, Kazuhiro Matsukawa, Hiroyoshi Shiozaki, Shigehiro Ichimura, Kouichi Okajima, Masazumi Ninomiya, Motoki Repeated resections for liver metastasis from primary adrenocortical carcinoma: A case report |
title | Repeated resections for liver metastasis from primary adrenocortical carcinoma: A case report |
title_full | Repeated resections for liver metastasis from primary adrenocortical carcinoma: A case report |
title_fullStr | Repeated resections for liver metastasis from primary adrenocortical carcinoma: A case report |
title_full_unstemmed | Repeated resections for liver metastasis from primary adrenocortical carcinoma: A case report |
title_short | Repeated resections for liver metastasis from primary adrenocortical carcinoma: A case report |
title_sort | repeated resections for liver metastasis from primary adrenocortical carcinoma: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392357/ https://www.ncbi.nlm.nih.gov/pubmed/25765741 http://dx.doi.org/10.1016/j.ijscr.2015.02.041 |
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