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Repeated resections for liver metastasis from primary adrenocortical carcinoma: A case report

INTRODUCTION: Adrenal cortical carcinoma (ACC) is a very rare type of tumor that generally has a poor prognosis. Little has been reported on repeated liver resections with recurrent metastasis still confined to the liver. In this report, we describe a case of functioning ACC in a 65-year-old woman w...

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Autores principales: Nakano, Ryosuke, Satoh, Daisuke, Nakajima, Hirochika, Yoshimura, Yuri, Miyoshi, Hisanobu, Yoshida, Kazuhiro, Matsukawa, Hiroyoshi, Shiozaki, Shigehiro, Ichimura, Kouichi, Okajima, Masazumi, Ninomiya, Motoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392357/
https://www.ncbi.nlm.nih.gov/pubmed/25765741
http://dx.doi.org/10.1016/j.ijscr.2015.02.041
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author Nakano, Ryosuke
Satoh, Daisuke
Nakajima, Hirochika
Yoshimura, Yuri
Miyoshi, Hisanobu
Yoshida, Kazuhiro
Matsukawa, Hiroyoshi
Shiozaki, Shigehiro
Ichimura, Kouichi
Okajima, Masazumi
Ninomiya, Motoki
author_facet Nakano, Ryosuke
Satoh, Daisuke
Nakajima, Hirochika
Yoshimura, Yuri
Miyoshi, Hisanobu
Yoshida, Kazuhiro
Matsukawa, Hiroyoshi
Shiozaki, Shigehiro
Ichimura, Kouichi
Okajima, Masazumi
Ninomiya, Motoki
author_sort Nakano, Ryosuke
collection PubMed
description INTRODUCTION: Adrenal cortical carcinoma (ACC) is a very rare type of tumor that generally has a poor prognosis. Little has been reported on repeated liver resections with recurrent metastasis still confined to the liver. In this report, we describe a case of functioning ACC in a 65-year-old woman with 2 liver metastases of the ACC (at 1.5 and 4 years) after the right adrenalectomy. PRESENTATION OF CASE: A 65-year-old woman was referred to our hospital based on a suspicion of hyperaldosteronism. Abdominal computed tomography revealed a lesion at the right adrenal gland; therefore, we performed right adrenalectomy and subsequently diagnosed the lesion as ACC. However, follow-up computed tomography at 1.5 and 4 years after the right adrenalectomy revealed liver metastasis of ACC; liver resection was performed for both metastases. DISCUSSION: Complete surgical resection is the established approach for the treatment of ACC. The prognosis of ACC is usually dismal, and recurrence rates of up to 85% have been reported. However, the appropriate treatment for recurrent ACC is not well established, and the effectiveness of other modalities, such as chemotherapy and radiotherapy, is not proven. Therefore, surgical resection may currently be the most appropriate treatment modality, as the patient achieved a disease-free interval of 2.5 years after the first liver resection. CONCLUSION: In selected patients with recurrent or metastatic ACC, resection is likely to be associated with prolonged survival. However, a full cure is generally not achievable, and a multidisciplinary approach is likely needed to achieve long-term disease-free status and survival.
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spelling pubmed-43923572015-04-13 Repeated resections for liver metastasis from primary adrenocortical carcinoma: A case report Nakano, Ryosuke Satoh, Daisuke Nakajima, Hirochika Yoshimura, Yuri Miyoshi, Hisanobu Yoshida, Kazuhiro Matsukawa, Hiroyoshi Shiozaki, Shigehiro Ichimura, Kouichi Okajima, Masazumi Ninomiya, Motoki Int J Surg Case Rep Case Report INTRODUCTION: Adrenal cortical carcinoma (ACC) is a very rare type of tumor that generally has a poor prognosis. Little has been reported on repeated liver resections with recurrent metastasis still confined to the liver. In this report, we describe a case of functioning ACC in a 65-year-old woman with 2 liver metastases of the ACC (at 1.5 and 4 years) after the right adrenalectomy. PRESENTATION OF CASE: A 65-year-old woman was referred to our hospital based on a suspicion of hyperaldosteronism. Abdominal computed tomography revealed a lesion at the right adrenal gland; therefore, we performed right adrenalectomy and subsequently diagnosed the lesion as ACC. However, follow-up computed tomography at 1.5 and 4 years after the right adrenalectomy revealed liver metastasis of ACC; liver resection was performed for both metastases. DISCUSSION: Complete surgical resection is the established approach for the treatment of ACC. The prognosis of ACC is usually dismal, and recurrence rates of up to 85% have been reported. However, the appropriate treatment for recurrent ACC is not well established, and the effectiveness of other modalities, such as chemotherapy and radiotherapy, is not proven. Therefore, surgical resection may currently be the most appropriate treatment modality, as the patient achieved a disease-free interval of 2.5 years after the first liver resection. CONCLUSION: In selected patients with recurrent or metastatic ACC, resection is likely to be associated with prolonged survival. However, a full cure is generally not achievable, and a multidisciplinary approach is likely needed to achieve long-term disease-free status and survival. Elsevier 2015-02-26 /pmc/articles/PMC4392357/ /pubmed/25765741 http://dx.doi.org/10.1016/j.ijscr.2015.02.041 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Nakano, Ryosuke
Satoh, Daisuke
Nakajima, Hirochika
Yoshimura, Yuri
Miyoshi, Hisanobu
Yoshida, Kazuhiro
Matsukawa, Hiroyoshi
Shiozaki, Shigehiro
Ichimura, Kouichi
Okajima, Masazumi
Ninomiya, Motoki
Repeated resections for liver metastasis from primary adrenocortical carcinoma: A case report
title Repeated resections for liver metastasis from primary adrenocortical carcinoma: A case report
title_full Repeated resections for liver metastasis from primary adrenocortical carcinoma: A case report
title_fullStr Repeated resections for liver metastasis from primary adrenocortical carcinoma: A case report
title_full_unstemmed Repeated resections for liver metastasis from primary adrenocortical carcinoma: A case report
title_short Repeated resections for liver metastasis from primary adrenocortical carcinoma: A case report
title_sort repeated resections for liver metastasis from primary adrenocortical carcinoma: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392357/
https://www.ncbi.nlm.nih.gov/pubmed/25765741
http://dx.doi.org/10.1016/j.ijscr.2015.02.041
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