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Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation

Exposure to high levels of ionizing radiation (IR) leads to debilitating and dose-limiting gastrointestinal (GI) toxicity. Using three-dimensional mouse crypt culture, we demonstrated that p53 target PUMA mediates radiation-induced apoptosis via a cell-intrinsic mechanism, and identified the GSK-3 i...

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Detalles Bibliográficos
Autores principales:	Wang, Xinwei, Wei, Liang, Cramer, Julie M., Leibowitz, Brian J., Judge, Colleen, Epperly, Michael, Greenberger, Joel, Wang, Fengchao, Li, Linheng, Stelzner, Matthias G., Dunn, James C. Y., Martin, Martin G., Lagasse, Eric, Zhang, Lin, Yu, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392360/ https://www.ncbi.nlm.nih.gov/pubmed/25858503 http://dx.doi.org/10.1038/srep08566

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