Renal Tubule Angiotensin II Type 1 Receptor–Associated Protein Promotes Natriuresis and Inhibits Salt‐Sensitive Blood Pressure Elevation

BACKGROUND: Angiotensin II type 1 receptor (AT1R)–associated protein (ATRAP; Agtrap gene) promotes AT1R internalization along with suppression of pathological AT1R activation. In this study, we examined whether enhancement of ATRAP in the renal distal tubules affects sodium handling and blood pressu...

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Detalles Bibliográficos
Autores principales: Wakui, Hiromichi, Uneda, Kazushi, Tamura, Kouichi, Ohsawa, Masato, Azushima, Kengo, Kobayashi, Ryu, Ohki, Kohji, Dejima, Toru, Kanaoka, Tomohiko, Tsurumi‐Ikeya, Yuko, Matsuda, Miyuki, Haruhara, Kotaro, Nishiyama, Akira, Yabana, Machiko, Fujikawa, Tetsuya, Yamashita, Akio, Umemura, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392439/
https://www.ncbi.nlm.nih.gov/pubmed/25792129
http://dx.doi.org/10.1161/JAHA.114.001594

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