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Disability-adjusted-life-years losses in postmenopausal women with osteoporosis: a burden of illness study

BACKGROUND: To estimate the disability-adjusted life years (DALY) in a nationwide representative sample of postmenopausal women with osteoporosis. The effects of drug-based therapy and risk factors for osteoporotic bone fractures on DALY losses were also explored. METHODS: DALY were estimated based...

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Autores principales: Darbà, Josep, Kaskens, Lisette, Pérez-Álvarez, Nuria, Palacios, Santiago, Neyro, José Luis, Rejas, Javier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392468/
https://www.ncbi.nlm.nih.gov/pubmed/25880810
http://dx.doi.org/10.1186/s12889-015-1684-7
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author Darbà, Josep
Kaskens, Lisette
Pérez-Álvarez, Nuria
Palacios, Santiago
Neyro, José Luis
Rejas, Javier
author_facet Darbà, Josep
Kaskens, Lisette
Pérez-Álvarez, Nuria
Palacios, Santiago
Neyro, José Luis
Rejas, Javier
author_sort Darbà, Josep
collection PubMed
description BACKGROUND: To estimate the disability-adjusted life years (DALY) in a nationwide representative sample of postmenopausal women with osteoporosis. The effects of drug-based therapy and risk factors for osteoporotic bone fractures on DALY losses were also explored. METHODS: DALY were estimated based on participant’s clinical characteristics and Health-Related Quality-of-Life (HRQoL) data obtained from a cross-sectional, epidemiological one-visit study (the GINERISK study). The study enrolled postmenopausal women (at least 12-months after their last menstrual period) with osteoporosis, above 18-years old, who attended Spanish outpatient Gynaecology clinics. HRQoL was assessed using the generic SF-12v2 questionnaire, which was used to derive disutility values. Mortality rates were extracted from the Spanish national statistics database. Factors explored to be associated with DALY losses were examined using ANOVA, ANCOVA and MANCOVA models. RESULTS: DALY could be computed in 2,782 (67%) out of 4,157 postmenopausal women, with a mean (95% CI) age of 61.0 (60.7-61.2) years. Overall individual undiscounted DALY per woman were 6.1 (5.9-6.2), resulting to be significantly higher in women with severe osteoporosis with prior bone fracture; 7.8 (7.2-8.4) compared to osteoporotic women [5.8 (5.6-6.0)] or postmenopausal women with a BMD > −2.5 T-score that received a drug-based therapy [6.2 (5.8-6.5)]; F = 27.0 (P < 0.01). Models explaining the variation in the levels of health based on the use of a selective estrogen receptor modulator (SERM) or possession of risk factors for osteoporotic BF were found (P < 0.05). CONCLUSIONS: DALY losses were considerable amongst postmenopausal women with osteoporosis. Not having a prior bone fracture, being older, using a SERM and having less osteoporotic risk factors were all linked to less DALY losses.
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spelling pubmed-43924682015-04-11 Disability-adjusted-life-years losses in postmenopausal women with osteoporosis: a burden of illness study Darbà, Josep Kaskens, Lisette Pérez-Álvarez, Nuria Palacios, Santiago Neyro, José Luis Rejas, Javier BMC Public Health Research Article BACKGROUND: To estimate the disability-adjusted life years (DALY) in a nationwide representative sample of postmenopausal women with osteoporosis. The effects of drug-based therapy and risk factors for osteoporotic bone fractures on DALY losses were also explored. METHODS: DALY were estimated based on participant’s clinical characteristics and Health-Related Quality-of-Life (HRQoL) data obtained from a cross-sectional, epidemiological one-visit study (the GINERISK study). The study enrolled postmenopausal women (at least 12-months after their last menstrual period) with osteoporosis, above 18-years old, who attended Spanish outpatient Gynaecology clinics. HRQoL was assessed using the generic SF-12v2 questionnaire, which was used to derive disutility values. Mortality rates were extracted from the Spanish national statistics database. Factors explored to be associated with DALY losses were examined using ANOVA, ANCOVA and MANCOVA models. RESULTS: DALY could be computed in 2,782 (67%) out of 4,157 postmenopausal women, with a mean (95% CI) age of 61.0 (60.7-61.2) years. Overall individual undiscounted DALY per woman were 6.1 (5.9-6.2), resulting to be significantly higher in women with severe osteoporosis with prior bone fracture; 7.8 (7.2-8.4) compared to osteoporotic women [5.8 (5.6-6.0)] or postmenopausal women with a BMD > −2.5 T-score that received a drug-based therapy [6.2 (5.8-6.5)]; F = 27.0 (P < 0.01). Models explaining the variation in the levels of health based on the use of a selective estrogen receptor modulator (SERM) or possession of risk factors for osteoporotic BF were found (P < 0.05). CONCLUSIONS: DALY losses were considerable amongst postmenopausal women with osteoporosis. Not having a prior bone fracture, being older, using a SERM and having less osteoporotic risk factors were all linked to less DALY losses. BioMed Central 2015-04-02 /pmc/articles/PMC4392468/ /pubmed/25880810 http://dx.doi.org/10.1186/s12889-015-1684-7 Text en © Darba et al.; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Darbà, Josep
Kaskens, Lisette
Pérez-Álvarez, Nuria
Palacios, Santiago
Neyro, José Luis
Rejas, Javier
Disability-adjusted-life-years losses in postmenopausal women with osteoporosis: a burden of illness study
title Disability-adjusted-life-years losses in postmenopausal women with osteoporosis: a burden of illness study
title_full Disability-adjusted-life-years losses in postmenopausal women with osteoporosis: a burden of illness study
title_fullStr Disability-adjusted-life-years losses in postmenopausal women with osteoporosis: a burden of illness study
title_full_unstemmed Disability-adjusted-life-years losses in postmenopausal women with osteoporosis: a burden of illness study
title_short Disability-adjusted-life-years losses in postmenopausal women with osteoporosis: a burden of illness study
title_sort disability-adjusted-life-years losses in postmenopausal women with osteoporosis: a burden of illness study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392468/
https://www.ncbi.nlm.nih.gov/pubmed/25880810
http://dx.doi.org/10.1186/s12889-015-1684-7
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