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Preventive Effect of Phytic Acid on Isoproterenol-Induced Cardiotoxicity in Wistar Rats
This study was aimed to evaluate the preventive role of phytic acid on membrane bound enzymes such as sodium potassium- dependent adenosine triphosphatase (Na(+) /K(+) ATPase), calcium-dependent adenosine triphosphatase (Ca(2+) ATPase) and magnesium- dependent adenosine triphosphatase (Mg(2+) ATPase...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Master Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392561/ |
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author | Brindha, E. Rajasekapandiyan, M. |
author_facet | Brindha, E. Rajasekapandiyan, M. |
author_sort | Brindha, E. |
collection | PubMed |
description | This study was aimed to evaluate the preventive role of phytic acid on membrane bound enzymes such as sodium potassium- dependent adenosine triphosphatase (Na(+) /K(+) ATPase), calcium-dependent adenosine triphosphatase (Ca(2+) ATPase) and magnesium- dependent adenosine triphosphatase (Mg(2+) ATPase) and glycoproteins such as hexose, hexosamine, fucose and sialic acid in isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Male albino Wistar rats were pretreated with phytic acid (25 and 50 mg/kg, respectively) for a period of 56 days. After the treatment period, ISO (85 mg/kg) was subcutaneously injected to rats at an interval of 24 h for 2 days. ISO-induced rats showed a significant decrease in the activity of Na(+) /K(+) ATPase and increase in the activities of Ca(2+) and Mg(2+) ATPase in the heart and a significant (P<0.05) increase in the levels of glycoproteins in serum and the heart were also observed in ISO-induced rats. Pretreatment with phytic acid for a period of 56 days exhibited a significant (P<0.05) effect and altered these biochemical parameters positively in ISO-induced rats. Thus, our study shows that phytic acid has cardioprotective role in ISO-induced MI in rats. |
format | Online Article Text |
id | pubmed-4392561 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Master Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-43925612015-04-15 Preventive Effect of Phytic Acid on Isoproterenol-Induced Cardiotoxicity in Wistar Rats Brindha, E. Rajasekapandiyan, M. Int J Biomed Sci Original Article This study was aimed to evaluate the preventive role of phytic acid on membrane bound enzymes such as sodium potassium- dependent adenosine triphosphatase (Na(+) /K(+) ATPase), calcium-dependent adenosine triphosphatase (Ca(2+) ATPase) and magnesium- dependent adenosine triphosphatase (Mg(2+) ATPase) and glycoproteins such as hexose, hexosamine, fucose and sialic acid in isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Male albino Wistar rats were pretreated with phytic acid (25 and 50 mg/kg, respectively) for a period of 56 days. After the treatment period, ISO (85 mg/kg) was subcutaneously injected to rats at an interval of 24 h for 2 days. ISO-induced rats showed a significant decrease in the activity of Na(+) /K(+) ATPase and increase in the activities of Ca(2+) and Mg(2+) ATPase in the heart and a significant (P<0.05) increase in the levels of glycoproteins in serum and the heart were also observed in ISO-induced rats. Pretreatment with phytic acid for a period of 56 days exhibited a significant (P<0.05) effect and altered these biochemical parameters positively in ISO-induced rats. Thus, our study shows that phytic acid has cardioprotective role in ISO-induced MI in rats. Master Publishing Group 2015-03 /pmc/articles/PMC4392561/ Text en © E. Brindha et al. Licensee Master Publishing Group http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Original Article Brindha, E. Rajasekapandiyan, M. Preventive Effect of Phytic Acid on Isoproterenol-Induced Cardiotoxicity in Wistar Rats |
title | Preventive Effect of Phytic Acid on Isoproterenol-Induced Cardiotoxicity in Wistar Rats |
title_full | Preventive Effect of Phytic Acid on Isoproterenol-Induced Cardiotoxicity in Wistar Rats |
title_fullStr | Preventive Effect of Phytic Acid on Isoproterenol-Induced Cardiotoxicity in Wistar Rats |
title_full_unstemmed | Preventive Effect of Phytic Acid on Isoproterenol-Induced Cardiotoxicity in Wistar Rats |
title_short | Preventive Effect of Phytic Acid on Isoproterenol-Induced Cardiotoxicity in Wistar Rats |
title_sort | preventive effect of phytic acid on isoproterenol-induced cardiotoxicity in wistar rats |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392561/ |
work_keys_str_mv | AT brindhae preventiveeffectofphyticacidonisoproterenolinducedcardiotoxicityinwistarrats AT rajasekapandiyanm preventiveeffectofphyticacidonisoproterenolinducedcardiotoxicityinwistarrats |