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Preventive Effect of Phytic Acid on Isoproterenol-Induced Cardiotoxicity in Wistar Rats

This study was aimed to evaluate the preventive role of phytic acid on membrane bound enzymes such as sodium potassium- dependent adenosine triphosphatase (Na(+) /K(+) ATPase), calcium-dependent adenosine triphosphatase (Ca(2+) ATPase) and magnesium- dependent adenosine triphosphatase (Mg(2+) ATPase...

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Autores principales: Brindha, E., Rajasekapandiyan, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Master Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392561/
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author Brindha, E.
Rajasekapandiyan, M.
author_facet Brindha, E.
Rajasekapandiyan, M.
author_sort Brindha, E.
collection PubMed
description This study was aimed to evaluate the preventive role of phytic acid on membrane bound enzymes such as sodium potassium- dependent adenosine triphosphatase (Na(+) /K(+) ATPase), calcium-dependent adenosine triphosphatase (Ca(2+) ATPase) and magnesium- dependent adenosine triphosphatase (Mg(2+) ATPase) and glycoproteins such as hexose, hexosamine, fucose and sialic acid in isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Male albino Wistar rats were pretreated with phytic acid (25 and 50 mg/kg, respectively) for a period of 56 days. After the treatment period, ISO (85 mg/kg) was subcutaneously injected to rats at an interval of 24 h for 2 days. ISO-induced rats showed a significant decrease in the activity of Na(+) /K(+) ATPase and increase in the activities of Ca(2+) and Mg(2+) ATPase in the heart and a significant (P<0.05) increase in the levels of glycoproteins in serum and the heart were also observed in ISO-induced rats. Pretreatment with phytic acid for a period of 56 days exhibited a significant (P<0.05) effect and altered these biochemical parameters positively in ISO-induced rats. Thus, our study shows that phytic acid has cardioprotective role in ISO-induced MI in rats.
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spelling pubmed-43925612015-04-15 Preventive Effect of Phytic Acid on Isoproterenol-Induced Cardiotoxicity in Wistar Rats Brindha, E. Rajasekapandiyan, M. Int J Biomed Sci Original Article This study was aimed to evaluate the preventive role of phytic acid on membrane bound enzymes such as sodium potassium- dependent adenosine triphosphatase (Na(+) /K(+) ATPase), calcium-dependent adenosine triphosphatase (Ca(2+) ATPase) and magnesium- dependent adenosine triphosphatase (Mg(2+) ATPase) and glycoproteins such as hexose, hexosamine, fucose and sialic acid in isoproterenol (ISO)-induced myocardial infarction (MI) in rats. Male albino Wistar rats were pretreated with phytic acid (25 and 50 mg/kg, respectively) for a period of 56 days. After the treatment period, ISO (85 mg/kg) was subcutaneously injected to rats at an interval of 24 h for 2 days. ISO-induced rats showed a significant decrease in the activity of Na(+) /K(+) ATPase and increase in the activities of Ca(2+) and Mg(2+) ATPase in the heart and a significant (P<0.05) increase in the levels of glycoproteins in serum and the heart were also observed in ISO-induced rats. Pretreatment with phytic acid for a period of 56 days exhibited a significant (P<0.05) effect and altered these biochemical parameters positively in ISO-induced rats. Thus, our study shows that phytic acid has cardioprotective role in ISO-induced MI in rats. Master Publishing Group 2015-03 /pmc/articles/PMC4392561/ Text en © E. Brindha et al. Licensee Master Publishing Group http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Brindha, E.
Rajasekapandiyan, M.
Preventive Effect of Phytic Acid on Isoproterenol-Induced Cardiotoxicity in Wistar Rats
title Preventive Effect of Phytic Acid on Isoproterenol-Induced Cardiotoxicity in Wistar Rats
title_full Preventive Effect of Phytic Acid on Isoproterenol-Induced Cardiotoxicity in Wistar Rats
title_fullStr Preventive Effect of Phytic Acid on Isoproterenol-Induced Cardiotoxicity in Wistar Rats
title_full_unstemmed Preventive Effect of Phytic Acid on Isoproterenol-Induced Cardiotoxicity in Wistar Rats
title_short Preventive Effect of Phytic Acid on Isoproterenol-Induced Cardiotoxicity in Wistar Rats
title_sort preventive effect of phytic acid on isoproterenol-induced cardiotoxicity in wistar rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392561/
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