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PU.1 downregulation in murine radiation-induced acute myeloid leukaemia (AML): from molecular mechanism to human AML
The transcription factor PU.1, encoded by the murine Sfpi1 gene (SPI1 in humans), is a member of the Ets transcription factor family and plays a vital role in commitment and maturation of the myeloid and lymphoid lineages. Murine studies directly link primary acute myeloid leukaemia (AML) and decrea...
Autores principales: | Verbiest, Tom, Bouffler, Simon, Nutt, Stephen L., Badie, Christophe |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392607/ https://www.ncbi.nlm.nih.gov/pubmed/25750172 http://dx.doi.org/10.1093/carcin/bgv016 |
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