Cargando…
Early cyclosporin A treatment retards axonal degeneration in an experimental peripheral nerve injection injury model
Injury to peripheral nerves during injections of therapeutic agents such as penicillin G potassium is common in developing countries. It has been shown that cyclosporin A, a powerful immunosuppressive agent, can retard Wallerian degeneration after peripheral nerve crush injury. However, few studies...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392675/ https://www.ncbi.nlm.nih.gov/pubmed/25883626 http://dx.doi.org/10.4103/1673-5374.152381 |
_version_ | 1782366030153121792 |
---|---|
author | Erkutlu, Ibrahim Alptekin, Mehmet Geyik, Sirma Geyik, Abidin Murat Gezgin, Inan Gök, Abdulvahap |
author_facet | Erkutlu, Ibrahim Alptekin, Mehmet Geyik, Sirma Geyik, Abidin Murat Gezgin, Inan Gök, Abdulvahap |
author_sort | Erkutlu, Ibrahim |
collection | PubMed |
description | Injury to peripheral nerves during injections of therapeutic agents such as penicillin G potassium is common in developing countries. It has been shown that cyclosporin A, a powerful immunosuppressive agent, can retard Wallerian degeneration after peripheral nerve crush injury. However, few studies are reported on the effects of cyclosporin A on peripheral nerve drug injection injury. This study aimed to assess the time-dependent efficacy of cyclosporine-A as an immunosuppressant therapy in an experimental rat nerve injection injury model established by penicillin G potassium injection. The rats were randomly divided into three groups based on the length of time after nerve injury induced by cyclosporine-A administration (30 minutes, 8 or 24 hours). The compound muscle action potentials were recorded pre-injury, early post-injury (within 1 hour) and 4 weeks after injury and compared statistically. Tissue samples were taken from each animal for histological analysis. Compared to the control group, a significant improvement of the compound muscle action potential amplitude value was observed only when cyclosporine-A was administered within 30 minutes of the injection injury (P < 0.05); at 8 or 24 hours after cyclosporine-A administration, compound muscle action potential amplitude was not changed compared with the control group. Thus, early immunosuppressant drug therapy may be a good alternative neuroprotective therapy option in experimental nerve injection injury induced by penicillin G potassium injection. |
format | Online Article Text |
id | pubmed-4392675 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-43926752015-04-16 Early cyclosporin A treatment retards axonal degeneration in an experimental peripheral nerve injection injury model Erkutlu, Ibrahim Alptekin, Mehmet Geyik, Sirma Geyik, Abidin Murat Gezgin, Inan Gök, Abdulvahap Neural Regen Res Research Article Injury to peripheral nerves during injections of therapeutic agents such as penicillin G potassium is common in developing countries. It has been shown that cyclosporin A, a powerful immunosuppressive agent, can retard Wallerian degeneration after peripheral nerve crush injury. However, few studies are reported on the effects of cyclosporin A on peripheral nerve drug injection injury. This study aimed to assess the time-dependent efficacy of cyclosporine-A as an immunosuppressant therapy in an experimental rat nerve injection injury model established by penicillin G potassium injection. The rats were randomly divided into three groups based on the length of time after nerve injury induced by cyclosporine-A administration (30 minutes, 8 or 24 hours). The compound muscle action potentials were recorded pre-injury, early post-injury (within 1 hour) and 4 weeks after injury and compared statistically. Tissue samples were taken from each animal for histological analysis. Compared to the control group, a significant improvement of the compound muscle action potential amplitude value was observed only when cyclosporine-A was administered within 30 minutes of the injection injury (P < 0.05); at 8 or 24 hours after cyclosporine-A administration, compound muscle action potential amplitude was not changed compared with the control group. Thus, early immunosuppressant drug therapy may be a good alternative neuroprotective therapy option in experimental nerve injection injury induced by penicillin G potassium injection. Medknow Publications & Media Pvt Ltd 2015-02 /pmc/articles/PMC4392675/ /pubmed/25883626 http://dx.doi.org/10.4103/1673-5374.152381 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Erkutlu, Ibrahim Alptekin, Mehmet Geyik, Sirma Geyik, Abidin Murat Gezgin, Inan Gök, Abdulvahap Early cyclosporin A treatment retards axonal degeneration in an experimental peripheral nerve injection injury model |
title | Early cyclosporin A treatment retards axonal degeneration in an experimental peripheral nerve injection injury model |
title_full | Early cyclosporin A treatment retards axonal degeneration in an experimental peripheral nerve injection injury model |
title_fullStr | Early cyclosporin A treatment retards axonal degeneration in an experimental peripheral nerve injection injury model |
title_full_unstemmed | Early cyclosporin A treatment retards axonal degeneration in an experimental peripheral nerve injection injury model |
title_short | Early cyclosporin A treatment retards axonal degeneration in an experimental peripheral nerve injection injury model |
title_sort | early cyclosporin a treatment retards axonal degeneration in an experimental peripheral nerve injection injury model |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392675/ https://www.ncbi.nlm.nih.gov/pubmed/25883626 http://dx.doi.org/10.4103/1673-5374.152381 |
work_keys_str_mv | AT erkutluibrahim earlycyclosporinatreatmentretardsaxonaldegenerationinanexperimentalperipheralnerveinjectioninjurymodel AT alptekinmehmet earlycyclosporinatreatmentretardsaxonaldegenerationinanexperimentalperipheralnerveinjectioninjurymodel AT geyiksirma earlycyclosporinatreatmentretardsaxonaldegenerationinanexperimentalperipheralnerveinjectioninjurymodel AT geyikabidinmurat earlycyclosporinatreatmentretardsaxonaldegenerationinanexperimentalperipheralnerveinjectioninjurymodel AT gezgininan earlycyclosporinatreatmentretardsaxonaldegenerationinanexperimentalperipheralnerveinjectioninjurymodel AT gokabdulvahap earlycyclosporinatreatmentretardsaxonaldegenerationinanexperimentalperipheralnerveinjectioninjurymodel |