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Discovery of YopE Inhibitors by Pharmacophore-Based Virtual Screening and Docking

Gram-negative bacteria Yersinia secrete virulence factors that invade eukaryotic cells via type III secretion system. One particular virulence member, Yersinia outer protein E (YopE), targets Rho family of small GTPases by mimicking regulator GAP protein activity, and its secretion mainly induces cy...

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Detalles Bibliográficos
Autores principales:	Ozbuyukkaya, Gizem, Ozkirimli Olmez, Elif, Ulgen, Kutlu O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393062/ https://www.ncbi.nlm.nih.gov/pubmed/25937949 http://dx.doi.org/10.1155/2013/640518

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