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Characterization of HTT Inclusion Size, Location, and Timing in the zQ175 Mouse Model of Huntington´s Disease: An In Vivo High-Content Imaging Study

Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG trinucleotide repeat expansion in the huntingtin gene. Major pathological hallmarks of HD include inclusions of mutant huntingtin (mHTT) protein, loss of neurons predominantly in the caudate nucleus, and at...

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Detalles Bibliográficos
Autores principales:	Carty, Nikisha, Berson, Nadège, Tillack, Karsten, Thiede, Christina, Scholz, Diana, Kottig, Karsten, Sedaghat, Yalda, Gabrysiak, Christina, Yohrling, George, von der Kammer, Heinz, Ebneth, Andreas, Mack, Volker, Munoz-Sanjuan, Ignacio, Kwak, Seung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393127/ https://www.ncbi.nlm.nih.gov/pubmed/25859666 http://dx.doi.org/10.1371/journal.pone.0123527

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