Functional Characterization of Human T Cell Hyporesponsiveness Induced by CTLA4-Ig

During activation, T cells integrate multiple signals from APCs and cytokine milieu. The blockade of these signals can have clinical benefits as exemplified by CTLA4-Ig, which blocks interaction of B7 co-stimulatory molecules on APCs with CD28 on T cells. Variants of CTLA4-Ig, abatacept and belatace...

Descripción completa

Detalles Bibliográficos
Autores principales: Rochman, Yrina, Yukawa, Masashi, Kartashov, Andrey V., Barski, Artem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393265/
https://www.ncbi.nlm.nih.gov/pubmed/25860138
http://dx.doi.org/10.1371/journal.pone.0122198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393265/
https://www.ncbi.nlm.nih.gov/pubmed/25860138
http://dx.doi.org/10.1371/journal.pone.0122198

Ejemplares similares