Bmp6 Expression in Murine Liver Non Parenchymal Cells: A Mechanism to Control their High Iron Exporter Activity and Protect Hepatocytes from Iron Overload?

Bmp6 is the main activator of hepcidin, the liver hormone that negatively regulates plasma iron influx by degrading the sole iron exporter ferroportin in enterocytes and macrophages. Bmp6 expression is modulated by iron but the molecular mechanisms are unknown. Although hepcidin is expressed almost...

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Detalles Bibliográficos
Autores principales: Rausa, Marco, Pagani, Alessia, Nai, Antonella, Campanella, Alessandro, Gilberti, Maria Enrica, Apostoli, Pietro, Camaschella, Clara, Silvestri, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393274/
https://www.ncbi.nlm.nih.gov/pubmed/25860887
http://dx.doi.org/10.1371/journal.pone.0122696

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