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Organic Carbamates in Drug Design and Medicinal Chemistry

[Image: see text] The carbamate group is a key structural motif in many approved drugs and prodrugs. There is an increasing use of carbamates in medicinal chemistry and many derivatives are specifically designed to make drug–target interactions through their carbamate moiety. In this Perspective, we...

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Autores principales: Ghosh, Arun K., Brindisi, Margherita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393377/
https://www.ncbi.nlm.nih.gov/pubmed/25565044
http://dx.doi.org/10.1021/jm501371s
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author Ghosh, Arun K.
Brindisi, Margherita
author_facet Ghosh, Arun K.
Brindisi, Margherita
author_sort Ghosh, Arun K.
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description [Image: see text] The carbamate group is a key structural motif in many approved drugs and prodrugs. There is an increasing use of carbamates in medicinal chemistry and many derivatives are specifically designed to make drug–target interactions through their carbamate moiety. In this Perspective, we present properties and stabilities of carbamates, reagents and chemical methodologies for the synthesis of carbamates, and recent applications of carbamates in drug design and medicinal chemistry.
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spelling pubmed-43933772016-01-07 Organic Carbamates in Drug Design and Medicinal Chemistry Ghosh, Arun K. Brindisi, Margherita J Med Chem [Image: see text] The carbamate group is a key structural motif in many approved drugs and prodrugs. There is an increasing use of carbamates in medicinal chemistry and many derivatives are specifically designed to make drug–target interactions through their carbamate moiety. In this Perspective, we present properties and stabilities of carbamates, reagents and chemical methodologies for the synthesis of carbamates, and recent applications of carbamates in drug design and medicinal chemistry. American Chemical Society 2015-01-07 2015-04-09 /pmc/articles/PMC4393377/ /pubmed/25565044 http://dx.doi.org/10.1021/jm501371s Text en Copyright © 2015 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Ghosh, Arun K.
Brindisi, Margherita
Organic Carbamates in Drug Design and Medicinal Chemistry
title Organic Carbamates in Drug Design and Medicinal Chemistry
title_full Organic Carbamates in Drug Design and Medicinal Chemistry
title_fullStr Organic Carbamates in Drug Design and Medicinal Chemistry
title_full_unstemmed Organic Carbamates in Drug Design and Medicinal Chemistry
title_short Organic Carbamates in Drug Design and Medicinal Chemistry
title_sort organic carbamates in drug design and medicinal chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393377/
https://www.ncbi.nlm.nih.gov/pubmed/25565044
http://dx.doi.org/10.1021/jm501371s
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