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Organic Carbamates in Drug Design and Medicinal Chemistry
[Image: see text] The carbamate group is a key structural motif in many approved drugs and prodrugs. There is an increasing use of carbamates in medicinal chemistry and many derivatives are specifically designed to make drug–target interactions through their carbamate moiety. In this Perspective, we...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393377/ https://www.ncbi.nlm.nih.gov/pubmed/25565044 http://dx.doi.org/10.1021/jm501371s |
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author | Ghosh, Arun K. Brindisi, Margherita |
author_facet | Ghosh, Arun K. Brindisi, Margherita |
author_sort | Ghosh, Arun K. |
collection | PubMed |
description | [Image: see text] The carbamate group is a key structural motif in many approved drugs and prodrugs. There is an increasing use of carbamates in medicinal chemistry and many derivatives are specifically designed to make drug–target interactions through their carbamate moiety. In this Perspective, we present properties and stabilities of carbamates, reagents and chemical methodologies for the synthesis of carbamates, and recent applications of carbamates in drug design and medicinal chemistry. |
format | Online Article Text |
id | pubmed-4393377 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | American Chemical
Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-43933772016-01-07 Organic Carbamates in Drug Design and Medicinal Chemistry Ghosh, Arun K. Brindisi, Margherita J Med Chem [Image: see text] The carbamate group is a key structural motif in many approved drugs and prodrugs. There is an increasing use of carbamates in medicinal chemistry and many derivatives are specifically designed to make drug–target interactions through their carbamate moiety. In this Perspective, we present properties and stabilities of carbamates, reagents and chemical methodologies for the synthesis of carbamates, and recent applications of carbamates in drug design and medicinal chemistry. American Chemical Society 2015-01-07 2015-04-09 /pmc/articles/PMC4393377/ /pubmed/25565044 http://dx.doi.org/10.1021/jm501371s Text en Copyright © 2015 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Ghosh, Arun K. Brindisi, Margherita Organic Carbamates in Drug Design and Medicinal Chemistry |
title | Organic Carbamates in Drug
Design and Medicinal Chemistry |
title_full | Organic Carbamates in Drug
Design and Medicinal Chemistry |
title_fullStr | Organic Carbamates in Drug
Design and Medicinal Chemistry |
title_full_unstemmed | Organic Carbamates in Drug
Design and Medicinal Chemistry |
title_short | Organic Carbamates in Drug
Design and Medicinal Chemistry |
title_sort | organic carbamates in drug
design and medicinal chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393377/ https://www.ncbi.nlm.nih.gov/pubmed/25565044 http://dx.doi.org/10.1021/jm501371s |
work_keys_str_mv | AT ghosharunk organiccarbamatesindrugdesignandmedicinalchemistry AT brindisimargherita organiccarbamatesindrugdesignandmedicinalchemistry |