Cargando…

Efficient in vivo antitumor effect of an immunotoxin based on ribotoxin α-sarcin in nude mice bearing human colorectal cancer xenografts

Tagging of RNases, such as the ribotoxin α-sarcin, with the variable domains of antibodies directed to surface antigens that are selectively expressed on tumor cells endows cellular specificity to their cytotoxic action. A recombinant single-chain immunotoxin based on the ribotoxin α-sarcin (IMTXA33...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tomé-Amat, Jaime, Olombrada, Miriam, Ruiz-de-la-Herrán, Javier, Pérez-Gómez, Eduardo, Andradas, Clara, Sánchez, Cristina, Martínez, Leopoldo, Martínez-del-Pozo, Álvaro, Gavilanes, José G, Lacadena, Javier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393403/ https://www.ncbi.nlm.nih.gov/pubmed/25883890 http://dx.doi.org/10.1186/s40064-015-0943-5

Ejemplares similares

Inclusion of a Furin Cleavage Site Enhances Antitumor Efficacy against Colorectal Cancer Cells of Ribotoxin α-Sarcin- or RNase T1-Based Immunotoxins
por: Ruiz-de-la-Herrán, Javier, et al.
Publicado: (2019)

A New Optimized Version of a Colorectal Cancer-Targeted Immunotoxin Based on a Non-Immunogenic Variant of the Ribotoxin α-Sarcin
por: Narbona, Javier, et al.
Publicado: (2023)

The ribotoxin α-sarcin can cleave the sarcin/ricin loop on late 60S pre-ribosomes
por: Olombrada, Miriam, et al.
Publicado: (2020)

A deimmunised form of the ribotoxin, α-sarcin, lacking CD4(+) T cell epitopes and its use as an immunotoxin warhead
por: Jones, Tim D., et al.
Publicado: (2016)

Hirsutellin A: A Paradigmatic Example of the Insecticidal Function of Fungal Ribotoxins
por: Herrero-Galán, Elías, et al.
Publicado: (2013)

Fungal Ribotoxins: A Review of Potential Biotechnological Applications
por: Olombrada, Miriam, et al.
Publicado: (2017)

A novel Carcinoembryonic Antigen (CEA)-Targeted Trimeric Immunotoxin shows significantly enhanced Antitumor Activity in Human Colorectal Cancer Xenografts
por: Lázaro-Gorines, R., et al.
Publicado: (2019)

Cleavage of the sarcin–ricin loop of 23S rRNA differentially affects EF-G and EF-Tu binding
por: García-Ortega, Lucía, et al.
Publicado: (2010)

Antibody-Based Immunotoxins for Colorectal Cancer Therapy
por: Sanz, Laura, et al.
Publicado: (2021)

Nanobody-Based EGFR-Targeting Immunotoxins for Colorectal Cancer Treatment
por: Narbona, Javier, et al.
Publicado: (2023)

Der p 1-based immunotoxin as potential tool for the treatment of dust mite respiratory allergy
por: Lázaro-Gorines, Rodrigo, et al.
Publicado: (2020)

Antitumor and Antiangiogenic Activities of Curcumin in Cervical Cancer Xenografts in Nude Mice
por: Yoysungnoen-Chintana, Pornphrom, et al.
Publicado: (2014)

alpha-Sarcin catalytic activity is not required for cytotoxicity
por: Alford, Spencer C, et al.
Publicado: (2009)

Ribotoxin genes in isolates of Aspergillus section Clavati
por: Varga, János, et al.
Publicado: (2008)

Molecular dynamics simulations of sarcin–ricin rRNA motif
por: Špačková, Nad'a, et al.
Publicado: (2006)

Antitumor Efficacy of Huqizhengxiao (HQZX) Decoction Based on Inhibition of Telomerase Activity in Nude Mice of Hepatocarcinoma Xenograft
por: Yu, XiaoXiao, et al.
Publicado: (2018)

Relationship of serum CEA levels to tumour size and CEA content in nude mice bearing colonic-tumour xenografts.
por: Lewis, J. C., et al.
Publicado: (1981)

Induction of apoptosis in human tumour xenografts after oral administration of uracil and tegafur to nude mice bearing tumours.
por: Oki, E., et al.
Publicado: (1998)

Mesenchymal stem cell-based NK4 gene therapy in nude mice bearing gastric cancer xenografts
por: Zhu, Yin, et al.
Publicado: (2014)

Determinants of eukaryal cell killing by the bacterial ribotoxin PrrC
por: Meineke, Birthe, et al.
Publicado: (2011)

Antitumor effects of inductive hyperthermia using magnetic ferucarbotran nanoparticles on human lung cancer xenografts in nude mice
por: Araya, Tomoyuki, et al.
Publicado: (2013)

Preclinical Studies of Granulysin-Based Anti-MUC1-Tn Immunotoxins as a New Antitumoral Treatment
por: Guerrero-Ochoa, Patricia, et al.
Publicado: (2022)

Differences in Ribosome Binding and Sarcin/Ricin Loop Depurination by Shiga and Ricin Holotoxins
por: Li, Xiao-Ping, et al.
Publicado: (2017)

RNA Probes for Visualization of Sarcin/ricin Loop Depurination without Background Fluorescence
por: Klimek, Robin, et al.
Publicado: (2022)

Enhanced delivery of paclitaxel liposomes using focused ultrasound with microbubbles for treating nude mice bearing intracranial glioblastoma xenografts
por: Shen, Yuanyuan, et al.
Publicado: (2017)

Antitumor and anti-metastatic effects of cyclooxygenase-2 inhibition by celecoxib on human colorectal carcinoma xenografts in nude mouse rectum
por: NINOMIYA, ITASU, et al.
Publicado: (2012)

Reliable Establishment of Human Sarcoma Xenografts in the Nude Rat
por: Tinkey, Peggy T., et al.
Publicado: (1999)

The development of xenograft glioblastoma implants in nude mice brain
por: Behar, FM, et al.
Publicado: (2008)

Whitefly genomes contain ribotoxin coding genes acquired from plants
por: Lapadula, Walter J., et al.
Publicado: (2020)

Localisation of [131I]MIBG in nude mice bearing SK-N-SH human neuroblastoma xenografts: effect of specific activity.
por: Vaidyanathan, G., et al.
Publicado: (1996)

FK317, a Novel Substituted Dihydrobenzoxazine, Exhibits Potent Antitumor Activity against Human Tumor Xenografts in Nude Mice
por: Naoe, Yoshinori, et al.
Publicado: (1998)

Cardamonin Exerts Antitumor Effect on Human Hepatocellular Carcinoma Xenografts in Athymic Nude Mice through Inhibiting NF-κβ Pathway
por: Badroon, Nassrin, et al.
Publicado: (2020)

Antitumor and antimetastasis effects of carboplatin liposomes with polyethylene glycol-2000 on SGC-7901 gastric cell-bearing nude mice
por: ZHANG, JIANZHONG, et al.
Publicado: (2014)

The transcriptome of the entomopathogenic fungus Culicinomyces clavisporus contains an ortholog of the insecticidal ribotoxin Hirsutellin
por: Foresman, Dana, et al.
Publicado: (2023)

Growth of human digestive-tumour xenografts in athymic nude rats.
por: Davies, G., et al.
Publicado: (1981)

BCG treatment of human tumour xenografts in athymic nude mice.
por: Pimm, M. V., et al.
Publicado: (1978)

Vascularity and perfusion of human gliomas xenografted in the athymic nude mouse.
por: Bernsen, H. J., et al.
Publicado: (1995)

Testosterone inhibits the growth of prostate cancer xenografts in nude mice
por: Song, Weitao, et al.
Publicado: (2017)

Soy isoflavone extracts stimulate the growth of nude mouse xenografts bearing estrogen-dependent human breast cancer cells (MCF-7)()
por: Wu, Qian, et al.
Publicado: (2012)

Biodistribution of Neocarzinostatin Conjugated to Chimeric Fab Fragments of the Monoclonal Antibody A7 in Nude Mice Bearing Human Pancreatic Cancer Xenografts
por: Otsuji, Eigo, et al.
Publicado: (1994)

Cannot write session to /tmp/vufind_sessions/sess_psb23akfia3md3dvn0j5i05lpl