Serum sickness following rabbit anti-thymocyte globulin for acute vascular renal allograft rejection

A simultaneous pancreas–kidney transplant recipient developed serum sickness manifesting with severe upper limb allodynia, arthralgia and myalgia 17 days following rabbit anti-thymocyte globulin (rATG) infusion for biopsy-proven vascular rejection. Rapid resolution of symptoms followed treatment wit...

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Detalles Bibliográficos
Autores principales: Teng, Jessie, Hoo, Xing Ning, Tan, Sven-Jean, Dwyer, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Clinical Cases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393471/
https://www.ncbi.nlm.nih.gov/pubmed/25874092
http://dx.doi.org/10.1093/ckj/sfs061
Descripción
Sumario:A simultaneous pancreas–kidney transplant recipient developed serum sickness manifesting with severe upper limb allodynia, arthralgia and myalgia 17 days following rabbit anti-thymocyte globulin (rATG) infusion for biopsy-proven vascular rejection. Rapid resolution of symptoms followed treatment with high-dose glucocorticoids. rATG is increasingly favoured over equine ATG in solid-organ transplantation, and although rATG has a superior safety profile, it is important to maintain a high index of suspicion for serum sickness.

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