Serum sickness following rabbit anti-thymocyte globulin for acute vascular renal allograft rejection

A simultaneous pancreas–kidney transplant recipient developed serum sickness manifesting with severe upper limb allodynia, arthralgia and myalgia 17 days following rabbit anti-thymocyte globulin (rATG) infusion for biopsy-proven vascular rejection. Rapid resolution of symptoms followed treatment wit...

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Autores principales: Teng, Jessie, Hoo, Xing Ning, Tan, Sven-Jean, Dwyer, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Clinical Cases
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393471/
https://www.ncbi.nlm.nih.gov/pubmed/25874092
http://dx.doi.org/10.1093/ckj/sfs061
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author Teng, Jessie
Hoo, Xing Ning
Tan, Sven-Jean
Dwyer, Karen
author_facet Teng, Jessie
Hoo, Xing Ning
Tan, Sven-Jean
Dwyer, Karen
author_sort Teng, Jessie
collection PubMed
description A simultaneous pancreas–kidney transplant recipient developed serum sickness manifesting with severe upper limb allodynia, arthralgia and myalgia 17 days following rabbit anti-thymocyte globulin (rATG) infusion for biopsy-proven vascular rejection. Rapid resolution of symptoms followed treatment with high-dose glucocorticoids. rATG is increasingly favoured over equine ATG in solid-organ transplantation, and although rATG has a superior safety profile, it is important to maintain a high index of suspicion for serum sickness.
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spelling pubmed-43934712015-04-13 Serum sickness following rabbit anti-thymocyte globulin for acute vascular renal allograft rejection Teng, Jessie Hoo, Xing Ning Tan, Sven-Jean Dwyer, Karen Clin Kidney J Clinical Cases A simultaneous pancreas–kidney transplant recipient developed serum sickness manifesting with severe upper limb allodynia, arthralgia and myalgia 17 days following rabbit anti-thymocyte globulin (rATG) infusion for biopsy-proven vascular rejection. Rapid resolution of symptoms followed treatment with high-dose glucocorticoids. rATG is increasingly favoured over equine ATG in solid-organ transplantation, and although rATG has a superior safety profile, it is important to maintain a high index of suspicion for serum sickness. Oxford University Press 2012-08 2012-06-13 /pmc/articles/PMC4393471/ /pubmed/25874092 http://dx.doi.org/10.1093/ckj/sfs061 Text en © The Author 2012. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Clinical Cases
Teng, Jessie
Hoo, Xing Ning
Tan, Sven-Jean
Dwyer, Karen
Serum sickness following rabbit anti-thymocyte globulin for acute vascular renal allograft rejection
title Serum sickness following rabbit anti-thymocyte globulin for acute vascular renal allograft rejection
title_full Serum sickness following rabbit anti-thymocyte globulin for acute vascular renal allograft rejection
title_fullStr Serum sickness following rabbit anti-thymocyte globulin for acute vascular renal allograft rejection
title_full_unstemmed Serum sickness following rabbit anti-thymocyte globulin for acute vascular renal allograft rejection
title_short Serum sickness following rabbit anti-thymocyte globulin for acute vascular renal allograft rejection
title_sort serum sickness following rabbit anti-thymocyte globulin for acute vascular renal allograft rejection
topic Clinical Cases
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393471/
https://www.ncbi.nlm.nih.gov/pubmed/25874092
http://dx.doi.org/10.1093/ckj/sfs061
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