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Immunity to diphtheria and tetanus among blood donors in Arak, central province of Iran

BACKGROUND AND OBJECTIVES: Tetanus and diphtheria are vaccine-preventable, infectious diseases with significant morbidity and mortality. Immunization by the diphtheria and tetanus toxoid (DT) has been applied in Iran for almost 50 years. However, there are very few data about the rate of immunity to...

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Autores principales: Eslamifar, Ali, Ramezani, Amitis, Banifazl, Mohammad, Sofian, Masoomeh, Mahdaviani, Fatemeh- Alsadat, Yaghmaie, Farhad, Aghakhani, Arezoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393496/
https://www.ncbi.nlm.nih.gov/pubmed/25870753
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author Eslamifar, Ali
Ramezani, Amitis
Banifazl, Mohammad
Sofian, Masoomeh
Mahdaviani, Fatemeh- Alsadat
Yaghmaie, Farhad
Aghakhani, Arezoo
author_facet Eslamifar, Ali
Ramezani, Amitis
Banifazl, Mohammad
Sofian, Masoomeh
Mahdaviani, Fatemeh- Alsadat
Yaghmaie, Farhad
Aghakhani, Arezoo
author_sort Eslamifar, Ali
collection PubMed
description BACKGROUND AND OBJECTIVES: Tetanus and diphtheria are vaccine-preventable, infectious diseases with significant morbidity and mortality. Immunization by the diphtheria and tetanus toxoid (DT) has been applied in Iran for almost 50 years. However, there are very few data about the rate of immunity to these diseases in the adult population. the humoral immunity to tetanus and diphtheria among blood donors in Arak city, central provice of Iran were investigated. PATIENTS & METHODS: A total of 530 consecutive blood donor samples were collected from Blood Transfusion Organization, Central province of Iran. All samples were tested for diphteria and tetanus IgG antibodies using enzyme-linked immunosorbent assay (ELISA). RESULTS: From 530 cases, 91.9% were male and 8.1% were female. 99.6% of cases had protective levels of diphtheria antibody. Protective levels of tetanus antibody were found in 96% of subjects. There was not any significant difference between diphtheria and tetanus antibodies levels and age and sex. CONCLUSION: The obtained data showed that high proportion of the adult population in Arak have sufficient protection against diphtheria and tetanus. The high protective level of immunity to diphtheria and tetanus in Iran can be due to widespread use of booster vaccines in Iranian high schools and during the military services or for pregnant women in their 3(rd) trimester.
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spelling pubmed-43934962015-04-13 Immunity to diphtheria and tetanus among blood donors in Arak, central province of Iran Eslamifar, Ali Ramezani, Amitis Banifazl, Mohammad Sofian, Masoomeh Mahdaviani, Fatemeh- Alsadat Yaghmaie, Farhad Aghakhani, Arezoo Iran J Microbiol Medical Sciences BACKGROUND AND OBJECTIVES: Tetanus and diphtheria are vaccine-preventable, infectious diseases with significant morbidity and mortality. Immunization by the diphtheria and tetanus toxoid (DT) has been applied in Iran for almost 50 years. However, there are very few data about the rate of immunity to these diseases in the adult population. the humoral immunity to tetanus and diphtheria among blood donors in Arak city, central provice of Iran were investigated. PATIENTS & METHODS: A total of 530 consecutive blood donor samples were collected from Blood Transfusion Organization, Central province of Iran. All samples were tested for diphteria and tetanus IgG antibodies using enzyme-linked immunosorbent assay (ELISA). RESULTS: From 530 cases, 91.9% were male and 8.1% were female. 99.6% of cases had protective levels of diphtheria antibody. Protective levels of tetanus antibody were found in 96% of subjects. There was not any significant difference between diphtheria and tetanus antibodies levels and age and sex. CONCLUSION: The obtained data showed that high proportion of the adult population in Arak have sufficient protection against diphtheria and tetanus. The high protective level of immunity to diphtheria and tetanus in Iran can be due to widespread use of booster vaccines in Iranian high schools and during the military services or for pregnant women in their 3(rd) trimester. Tehran University of Medical Sciences 2014-06 /pmc/articles/PMC4393496/ /pubmed/25870753 Text en Copyright: © Iranian Journal of Microbiology & Tehran University of Medical Sciences This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Medical Sciences
Eslamifar, Ali
Ramezani, Amitis
Banifazl, Mohammad
Sofian, Masoomeh
Mahdaviani, Fatemeh- Alsadat
Yaghmaie, Farhad
Aghakhani, Arezoo
Immunity to diphtheria and tetanus among blood donors in Arak, central province of Iran
title Immunity to diphtheria and tetanus among blood donors in Arak, central province of Iran
title_full Immunity to diphtheria and tetanus among blood donors in Arak, central province of Iran
title_fullStr Immunity to diphtheria and tetanus among blood donors in Arak, central province of Iran
title_full_unstemmed Immunity to diphtheria and tetanus among blood donors in Arak, central province of Iran
title_short Immunity to diphtheria and tetanus among blood donors in Arak, central province of Iran
title_sort immunity to diphtheria and tetanus among blood donors in arak, central province of iran
topic Medical Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393496/
https://www.ncbi.nlm.nih.gov/pubmed/25870753
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