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Phosphorylation of pyruvate kinase M2 and lactate dehydrogenase A by fibroblast growth factor receptor 1 in benign and malignant thyroid tissue

BACKGROUND: Lactate dehydrogenase A (LDHA) and Pyruvate Kinase M2 (PKM2) are important enzymes of glycolysis. Both of them can be phosphorylated and therefore regulated by Fibroblast growth factor receptor 1 (FGFR1). While phosphorylation of LDHA at tyrosine10 leads to tetramerization and activation...

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Detalles Bibliográficos
Autores principales:	Kachel, Paul, Trojanowicz, Bogusz, Sekulla, Carsten, Prenzel, Hanna, Dralle, Henning, Hoang-Vu, Cuong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393606/ https://www.ncbi.nlm.nih.gov/pubmed/25880801 http://dx.doi.org/10.1186/s12885-015-1135-y

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