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To Evaluate the Damage of Renal Function in CIAKI Rats at 3T: Using ASL and BOLD MRI

Purpose. To investigate noninvasive arterial spin-labeling (ASL) and blood oxygen level-dependent imaging (BOLD) sequences for measuring renal hemodynamics and oxygenation in contrast induced acute kidney injury (CIAKI) rat. Materials and Methods. Thirteen SD rats were randomly grouped into CIAKI gr...

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Autores principales: Chen, Wen-bo, Liang, Long, Zhang, Bin, Liu, Chun-ling, Liu, Hong-jun, Luo, Hai-ying, Zeng, Qiong-xin, Liang, Chang-hong, Liu, Guan-shu, Zhang, Shui-xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393899/
https://www.ncbi.nlm.nih.gov/pubmed/25893196
http://dx.doi.org/10.1155/2015/593060
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author Chen, Wen-bo
Liang, Long
Zhang, Bin
Liu, Chun-ling
Liu, Hong-jun
Luo, Hai-ying
Zeng, Qiong-xin
Liang, Chang-hong
Liu, Guan-shu
Zhang, Shui-xing
author_facet Chen, Wen-bo
Liang, Long
Zhang, Bin
Liu, Chun-ling
Liu, Hong-jun
Luo, Hai-ying
Zeng, Qiong-xin
Liang, Chang-hong
Liu, Guan-shu
Zhang, Shui-xing
author_sort Chen, Wen-bo
collection PubMed
description Purpose. To investigate noninvasive arterial spin-labeling (ASL) and blood oxygen level-dependent imaging (BOLD) sequences for measuring renal hemodynamics and oxygenation in contrast induced acute kidney injury (CIAKI) rat. Materials and Methods. Thirteen SD rats were randomly grouped into CIAKI group and control group. Both ASL and BOLD sequences were performed at 24 h preinjection and at intervals of 0.5, 12, 24, 48, 72, and 96 h postinjection to assess renal blood flow (RBF) and relative spin-spin relaxation rate (R (2) (*)), respectively. Results. For the CIAKI group, the value of RBF in the cortex (CO) and outer medulla (OM) of the kidney was significantly decreased (P < 0.05) at 12–48 h and regressed to baseline level (P = NS) at 72–96 h. In OM, the value of R (2) (*) was increased at 0.5–48 h (P < 0.05) and not statistically significant (P = NS) at 72 and 96 h. Conclusions. RBF in OM and CO and oxygen level in OM were decreased postinjection of CM. ASL combining BOLD can further identify the primary cause of the decrease of renal oxygenation in CIAKI. This approach provides means for noninvasive monitoring renal function during the first 4 days of CIAKI in clinical routine work.
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spelling pubmed-43938992015-04-19 To Evaluate the Damage of Renal Function in CIAKI Rats at 3T: Using ASL and BOLD MRI Chen, Wen-bo Liang, Long Zhang, Bin Liu, Chun-ling Liu, Hong-jun Luo, Hai-ying Zeng, Qiong-xin Liang, Chang-hong Liu, Guan-shu Zhang, Shui-xing Biomed Res Int Research Article Purpose. To investigate noninvasive arterial spin-labeling (ASL) and blood oxygen level-dependent imaging (BOLD) sequences for measuring renal hemodynamics and oxygenation in contrast induced acute kidney injury (CIAKI) rat. Materials and Methods. Thirteen SD rats were randomly grouped into CIAKI group and control group. Both ASL and BOLD sequences were performed at 24 h preinjection and at intervals of 0.5, 12, 24, 48, 72, and 96 h postinjection to assess renal blood flow (RBF) and relative spin-spin relaxation rate (R (2) (*)), respectively. Results. For the CIAKI group, the value of RBF in the cortex (CO) and outer medulla (OM) of the kidney was significantly decreased (P < 0.05) at 12–48 h and regressed to baseline level (P = NS) at 72–96 h. In OM, the value of R (2) (*) was increased at 0.5–48 h (P < 0.05) and not statistically significant (P = NS) at 72 and 96 h. Conclusions. RBF in OM and CO and oxygen level in OM were decreased postinjection of CM. ASL combining BOLD can further identify the primary cause of the decrease of renal oxygenation in CIAKI. This approach provides means for noninvasive monitoring renal function during the first 4 days of CIAKI in clinical routine work. Hindawi Publishing Corporation 2015 2015-03-29 /pmc/articles/PMC4393899/ /pubmed/25893196 http://dx.doi.org/10.1155/2015/593060 Text en Copyright © 2015 Wen-bo Chen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chen, Wen-bo
Liang, Long
Zhang, Bin
Liu, Chun-ling
Liu, Hong-jun
Luo, Hai-ying
Zeng, Qiong-xin
Liang, Chang-hong
Liu, Guan-shu
Zhang, Shui-xing
To Evaluate the Damage of Renal Function in CIAKI Rats at 3T: Using ASL and BOLD MRI
title To Evaluate the Damage of Renal Function in CIAKI Rats at 3T: Using ASL and BOLD MRI
title_full To Evaluate the Damage of Renal Function in CIAKI Rats at 3T: Using ASL and BOLD MRI
title_fullStr To Evaluate the Damage of Renal Function in CIAKI Rats at 3T: Using ASL and BOLD MRI
title_full_unstemmed To Evaluate the Damage of Renal Function in CIAKI Rats at 3T: Using ASL and BOLD MRI
title_short To Evaluate the Damage of Renal Function in CIAKI Rats at 3T: Using ASL and BOLD MRI
title_sort to evaluate the damage of renal function in ciaki rats at 3t: using asl and bold mri
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393899/
https://www.ncbi.nlm.nih.gov/pubmed/25893196
http://dx.doi.org/10.1155/2015/593060
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