Cargando…

Functional implications of a psychiatric risk variant within CACNA1C in induced human neurons

Psychiatric disorders have clear heritable risk. Several large-scale genome-wide association studies have revealed a strong association between susceptibility for psychiatric disorders, including bipolar disease, schizophrenia, and major depression, and a haplotype located in an intronic region of t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yoshimizu, Takao, Pan, Jen Q., Mungenast, Alison E., Madison, Jon M., Su, Susan, Ketterman, Josh, Ongur, Dost, McPhie, Donna, Cohen, Bruce, Perlis, Roy, Tsai, Li-Huei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394050/ https://www.ncbi.nlm.nih.gov/pubmed/25403839 http://dx.doi.org/10.1038/mp.2014.143

Ejemplares similares

Probing myelin and axon abnormalities separately in psychiatric disorders using MRI techniques
por: Du, Fei, et al.
Publicado: (2013)

Survey of quality and clarity of methods and results reporting in 1 year of intervention studies published in high-impact medical and psychiatric journals
por: Ravichandran, Caitlin, et al.
Publicado: (2022)

Oligodendrocyte differentiation of induced pluripotent stem cells derived from subjects with schizophrenias implicate abnormalities in development
por: McPhie, Donna L., et al.
Publicado: (2018)

Sprouty2 in the Dorsal Hippocampus Regulates Neurogenesis and Stress Responsiveness in Rats
por: Dow, Antonia L., et al.
Publicado: (2015)

Using Smartphone Apps to Promote Psychiatric Rehabilitation in a Peer-Led Community Support Program: Pilot Study
por: Mueller, Nora E, et al.
Publicado: (2018)

Disease-specific differences in gene expression, mitochondrial function and mitochondria-endoplasmic reticulum interactions in iPSC-derived cerebral organoids and cortical neurons in schizophrenia and bipolar disorder
por: Kathuria, Annie, et al.
Publicado: (2023)

10.4 DIFFUSION WEIGHTED SPECTROSCOPY STUDIES OF CELL-TYPE SPECIFIC ABNORMALITIES IN SCHIZOPHRENIA
por: Ongur, Dost
Publicado: (2018)

Transcriptome analysis and functional characterization of cerebral organoids in bipolar disorder
por: Kathuria, Annie, et al.
Publicado: (2020)

Synaptic deficits in iPSC-derived cortical interneurons in schizophrenia are mediated by NLGN2 and rescued by N-acetylcysteine
por: Kathuria, Annie, et al.
Publicado: (2019)

Clinical Features of Psychotic Disorders: Comparing Categorical and Dimensional Models
por: Ravichandran, Caitlin, et al.
Publicado: (2020)

Pyoderma gangrenosum treated with secukinumab: A case report
por: McPhie, Meghan L, et al.
Publicado: (2020)

Targeting the ubiquitin system by fragment-based drug discovery
por: Kennedy, Cassandra, et al.
Publicado: (2022)

APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain
por: Chen, Yuzhi, et al.
Publicado: (2003)

Decreased peak alpha frequency and impaired visual evoked potentials in first episode psychosis
por: Murphy, Michael, et al.
Publicado: (2019)

Thought disorder is correlated with atypical spoken binomial orderings
por: Murphy, Michael, et al.
Publicado: (2022)

Concomitant Calcium Channelopathies Involving CACNA1A and CACNA1F: A Case Report and Review of the Literature
por: Schaare, Donna, et al.
Publicado: (2023)

A projection for psychiatry in the post-COVID-19 era: potential trends, challenges, and directions
por: Türközer, Halide Bilge, et al.
Publicado: (2020)

Binding of Factor VIII to Lipid Nanodiscs Increases its Clotting Function in a Mouse Model of Hemophilia A
por: Csencsits-Smith, Keri, et al.
Publicado: (2015)

Lichen planopilaris induced by infliximab: A case report
por: McPhie, Meghan L, et al.
Publicado: (2020)

Improvement of granulomatous skin conditions with tofacitinib in three patients: A case report
por: McPhie, Meghan L, et al.
Publicado: (2021)

Psychiatric risk gene Cacna1c determines mitochondrial resilience against oxidative stress in neurons
por: Michels, Susanne, et al.
Publicado: (2018)

Genetic Variation in the Psychiatric Risk Gene CACNA1C Modulates Reversal Learning Across Species
por: Sykes, Lucy, et al.
Publicado: (2019)

Perineal hernia as a sequela of anal reconstruction surgeries in perianal Crohn's disease
por: Garuba, Favour O., et al.
Publicado: (2023)

COVID-19 testing and patients in mental health facilities
por: Benson, Nicole M, et al.
Publicado: (2020)

Late-onset Alzheimer’s disease is associated with inherent changes in bioenergetics profiles
por: Sonntag, Kai-C., et al.
Publicado: (2017)

APP-BP1 inhibits Aβ42 levels by interacting with Presenilin-1
por: Chen, Yuzhi, et al.
Publicado: (2007)

Association of single nucleotide polymorphisms in CACNA 1A/CACNA 1C/CACNA 1H calcium channel genes with diabetic peripheral neuropathy in Chinese population
por: Sun, Lin, et al.
Publicado: (2018)

Aberrant cerebellar connectivity in motor and association networks in schizophrenia
por: Shinn, Ann K., et al.
Publicado: (2015)

Downregulation of the psychiatric susceptibility gene Cacna1c promotes mitochondrial resilience to oxidative stress in neuronal cells
por: Michels, Susanne, et al.
Publicado: (2018)

Do Copy Number Changes in CACNA2D2, CACNA2D3, and CACNA1D Constitute a Predisposing Risk Factor for Alzheimer’s Disease?
por: Villela, Darine, et al.
Publicado: (2016)

White Matter Measures and Cognition in Schizophrenia
por: Erkol, Cemre, et al.
Publicado: (2020)

Detection of Intranasally Delivered Bone Marrow-Derived Mesenchymal Stromal Cells in the Lesioned Mouse Brain: A Cautionary Report
por: Chartoff, Elena H., et al.
Publicado: (2011)

Cross-disorder risk gene CACNA1C differentially modulates susceptibility to psychiatric disorders during development and adulthood
por: Dedic, N, et al.
Publicado: (2018)

Decreased Nucleus Accumbens Expression of Psychiatric Disorder Risk Gene Cacna1c Promotes Susceptibility to Social Stress
por: Terrillion, Chantelle E., et al.
Publicado: (2017)

Long-read sequencing reveals the complex splicing profile of the psychiatric risk gene CACNA1C in human brain
por: Clark, Michael B., et al.
Publicado: (2019)

Neurotrophin receptor activation rescues cognitive and synaptic abnormalities caused by hemizygosity of the psychiatric risk gene Cacna1c
por: Tigaret, Cezar M., et al.
Publicado: (2021)

Cognitive Vulnerability to Major Depression: View from the Intrinsic Network and Cross-network Interactions
por: Wang, Xiang, et al.
Publicado: (2016)

Systematic Review of Interventions to Increase Awareness of Ultraviolet Radiation-Induced Harm and Protective Behaviors in Post-Secondary School Adults
por: Asai, Yuka, et al.
Publicado: (2021)

Redox and Immune Signaling in Schizophrenia: New Therapeutic Potential
por: Dwir, Daniella, et al.
Publicado: (2023)

Pandemic clinical case definitions are non-specific: multiple respiratory viruses circulating in the early phases of the 2009 influenza pandemic in New South Wales, Australia
por: Ratnamohan, Vigneswary Mala, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_dbd6jh15nu27el1kc79hgv61l9