Controlled induction of DNA double-strand breaks in the mouse liver induces features of tissue ageing

DNA damage has been implicated in ageing, but direct evidence for a causal relationship is lacking, owing to the difficulty of inducing defined DNA lesions in cells and tissues without simultaneously damaging other biomolecules and cellular structures. Here we directly test whether highly toxic DNA...

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Detalles Bibliográficos
Autores principales: White, Ryan R., Milholland, Brandon, de Bruin, Alain, Curran, Samuel, Laberge, Remi-Martin, van Steeg, Harry, Campisi, Judith, Maslov, Alexander Y., Vijg, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394211/
https://www.ncbi.nlm.nih.gov/pubmed/25858675
http://dx.doi.org/10.1038/ncomms7790

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