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γ-secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42)/Aβ(40) ratio

Markers for caspase activation and apoptosis have been shown in brains of Alzheimer’s disease (AD) patients and AD-mouse models. In neurons, caspase activation is associated with elevated amyloid β-peptide (Aβ) production. Caspases cleave numerous substrates including presenilin-1 (PS1). The cleavag...

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Detalles Bibliográficos
Autores principales:	Hedskog, Louise, Petersen, Camilla A Hansson, Svensson, Annelie I, Welander, Hedvig, Tjernberg, Lars O, Karlström, Helena, Ankarcrona, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2011
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4394225/ https://www.ncbi.nlm.nih.gov/pubmed/21054783 http://dx.doi.org/10.1111/j.1582-4934.2010.01208.x

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